2021 Big 12 Conference Leaders Opponent First Downs - Games vs. FBS non-Power 5 Conference Teams Only through 01/10/2022
| Name | G | Rush | Pass | Penalty | Total | Total/G | |
|---|---|---|---|---|---|---|---|
| 1 | Iowa State | 1 | 3 | 3 | 1 | 7 | 7.0 |
| 2 | Texas Tech | 2 | 9 | 13 | 3 | 25 | 12.5 |
| 3 | Kansas State | 1 | 5 | 9 | 0 | 14 | 14.0 |
| 4 | Baylor | 2 | 9 | 21 | 4 | 34 | 17.0 |
| 5 | Texas | 2 | 14 | 21 | 1 | 36 | 18.0 |
| 6 | Oklahoma State | 3 | 13 | 45 | 6 | 64 | 21.3 |
| 7 | Oklahoma | 1 | 8 | 14 | 2 | 24 | 24.0 |
| 8 | Kansas | 1 | 13 | 12 | 2 | 27 | 27.0 |
| 9 | TCU | 1 | 19 | 10 | 0 | 29 | 29.0 |