2021 Big 12 Conference Leaders Passing Defense - Games in December/January Only through 01/10/2022
| Name | G | Att | Comp | Pct. | Yards | Yards/Att | TD | Int | Rating | Att/G | Yards/G | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Texas Tech | 1 | 53 | 32 | 60.4 | 290 | 5.5 | 1 | 1 | 108.80 | 53.0 | 290.0 |
| 2 | Baylor | 2 | 81 | 49 | 60.5 | 447 | 5.5 | 1 | 7 | 93.65 | 40.5 | 223.5 |
| 3 | West Virginia | 1 | 13 | 8 | 61.5 | 109 | 8.4 | 0 | 1 | 116.59 | 13.0 | 109.0 |
| 4 | Oklahoma State | 2 | 96 | 61 | 63.5 | 689 | 7.2 | 8 | 1 | 149.25 | 48.0 | 344.5 |
| 5 | Kansas State | 1 | 11 | 7 | 63.6 | 138 | 12.5 | 3 | 2 | 222.66 | 11.0 | 138.0 |
| 5 | Iowa State | 1 | 33 | 21 | 63.6 | 187 | 5.7 | 0 | 1 | 105.18 | 33.0 | 187.0 |
| 7 | Oklahoma | 1 | 40 | 27 | 67.5 | 306 | 7.7 | 3 | 1 | 151.51 | 40.0 | 306.0 |