2021 Big 12 Conference Leaders Passing Defense - Games vs. Conference Teams Only through 01/10/2022
| Name | G | Att | Comp | Pct. | Yards | Yards/Att | TD | Int | Rating | Att/G | Yards/G | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Oklahoma State | 10 | 281 | 159 | 56.6 | 1734 | 6.2 | 10 | 7 | 115.18 | 28.1 | 173.4 |
| 2 | Baylor | 10 | 317 | 196 | 61.8 | 2390 | 7.5 | 10 | 13 | 127.37 | 31.7 | 239.0 |
| 3 | Iowa State | 9 | 242 | 150 | 62.0 | 1818 | 7.5 | 17 | 7 | 142.47 | 26.9 | 202.0 |
| 4 | West Virginia | 9 | 267 | 172 | 64.4 | 2026 | 7.6 | 12 | 8 | 137.00 | 29.7 | 225.1 |
| 5 | Texas | 9 | 294 | 194 | 66.0 | 2140 | 7.3 | 15 | 6 | 139.89 | 32.7 | 237.8 |
| 6 | Oklahoma | 9 | 299 | 199 | 66.6 | 2389 | 8.0 | 19 | 8 | 149.30 | 33.2 | 265.4 |
| 7 | TCU | 9 | 241 | 162 | 67.2 | 2247 | 9.3 | 14 | 6 | 159.73 | 26.8 | 249.7 |
| 8 | Texas Tech | 9 | 276 | 190 | 68.8 | 2489 | 9.0 | 23 | 4 | 169.19 | 30.7 | 276.6 |
| 9 | Kansas State | 9 | 267 | 184 | 68.9 | 1984 | 7.4 | 10 | 5 | 139.94 | 29.7 | 220.4 |
| 10 | Kansas | 9 | 242 | 172 | 71.1 | 2166 | 9.0 | 24 | 6 | 174.02 | 26.9 | 240.7 |