2021 Big 12 Conference Leaders Rushing Defense - Games in December/January Only through 01/10/2022
| Name | G | Att | Yards | Avg. | TD | Att/G | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Oklahoma State | 2 | 54 | 104 | 1.93 | 0 | 27.00 | 52.00 |
| 1 | Texas Tech | 1 | 20 | 54 | 2.70 | 0 | 20.00 | 54.00 |
| 1 | Kansas State | 1 | 37 | 170 | 4.59 | 0 | 37.00 | 170.00 |
| 4 | Baylor | 2 | 94 | 204 | 2.17 | 1 | 47.00 | 102.00 |
| 4 | Iowa State | 1 | 40 | 128 | 3.20 | 1 | 40.00 | 128.00 |
| 4 | Oklahoma | 1 | 33 | 191 | 5.79 | 1 | 33.00 | 191.00 |
| 7 | West Virginia | 1 | 51 | 249 | 4.88 | 2 | 51.00 | 249.00 |