2021 Big 12 Conference Leaders Rushing Defense - Games Lost Only through 01/10/2022
| Name | G | Att | Yards | Avg. | TD | Att/G | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Oklahoma State | 2 | 66 | 129 | 1.95 | 1 | 33.00 | 64.50 |
| 2 | Baylor | 2 | 94 | 313 | 3.33 | 3 | 47.00 | 156.50 |
| 3 | Oklahoma | 2 | 83 | 437 | 5.27 | 5 | 41.50 | 218.50 |
| 4 | Kansas State | 5 | 202 | 861 | 4.26 | 7 | 40.40 | 172.20 |
| 5 | West Virginia | 7 | 257 | 985 | 3.83 | 9 | 36.71 | 140.71 |
| 5 | Iowa State | 6 | 209 | 851 | 4.07 | 9 | 34.83 | 141.83 |
| 7 | Texas Tech | 6 | 246 | 1241 | 5.04 | 13 | 41.00 | 206.83 |
| 8 | Texas | 7 | 300 | 1674 | 5.58 | 19 | 42.86 | 239.14 |
| 9 | TCU | 7 | 300 | 1953 | 6.51 | 25 | 42.86 | 279.00 |
| 10 | Kansas | 10 | 422 | 2669 | 6.32 | 37 | 42.20 | 266.90 |