2021 Big 12 Conference Leaders Rushing Defense - Games in October Only through 01/10/2022
| Name | G | Att | Yards | Avg. | TD | Att/G | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Iowa State | 4 | 138 | 540 | 3.91 | 4 | 34.50 | 135.00 |
| 1 | Oklahoma | 5 | 165 | 681 | 4.13 | 4 | 33.00 | 136.20 |
| 3 | Oklahoma State | 4 | 128 | 411 | 3.21 | 5 | 32.00 | 102.75 |
| 4 | Baylor | 4 | 150 | 478 | 3.19 | 6 | 37.50 | 119.50 |
| 4 | West Virginia | 4 | 130 | 639 | 4.92 | 6 | 32.50 | 159.75 |
| 6 | Texas Tech | 5 | 156 | 776 | 4.97 | 8 | 31.20 | 155.20 |
| 6 | Kansas State | 4 | 145 | 667 | 4.60 | 8 | 36.25 | 166.75 |
| 8 | Texas | 4 | 174 | 959 | 5.51 | 10 | 43.50 | 239.75 |
| 9 | Kansas | 4 | 156 | 1039 | 6.66 | 14 | 39.00 | 259.75 |
| 10 | TCU | 5 | 200 | 1091 | 5.46 | 15 | 40.00 | 218.20 |