2021 Big 12 Conference Leaders Passing Defense - Games in October Only through 01/10/2022
| Name | G | Att | Comp | Pct. | Yards | Yards/Att | TD | Int | Rating | Att/G | Yards/G | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Oklahoma State | 4 | 106 | 64 | 60.4 | 703 | 6.6 | 3 | 5 | 116.00 | 26.5 | 175.8 |
| 2 | Texas | 4 | 132 | 81 | 61.4 | 879 | 6.7 | 5 | 4 | 123.74 | 33.0 | 219.8 |
| 3 | Kansas State | 4 | 100 | 73 | 73.0 | 801 | 8.0 | 3 | 2 | 146.18 | 25.0 | 200.3 |
| 3 | Iowa State | 4 | 116 | 71 | 61.2 | 928 | 8.0 | 8 | 4 | 144.27 | 29.0 | 232.0 |
| 5 | Baylor | 4 | 129 | 82 | 63.6 | 1076 | 8.3 | 5 | 5 | 138.67 | 32.3 | 269.0 |
| 6 | Kansas | 4 | 104 | 72 | 69.2 | 889 | 8.5 | 11 | 2 | 172.08 | 26.0 | 222.3 |
| 7 | West Virginia | 4 | 119 | 75 | 63.0 | 1049 | 8.8 | 6 | 3 | 148.68 | 29.8 | 262.3 |
| 8 | TCU | 5 | 136 | 88 | 64.7 | 1281 | 9.4 | 6 | 3 | 153.98 | 27.2 | 256.2 |
| 9 | Texas Tech | 5 | 138 | 101 | 73.2 | 1337 | 9.7 | 12 | 1 | 181.82 | 27.6 | 267.4 |
| 9 | Oklahoma | 5 | 162 | 110 | 67.9 | 1569 | 9.7 | 15 | 2 | 177.33 | 32.4 | 313.8 |