2021 Big 12 Conference Leaders Passing Defense - Games vs. FBS Power 5 Conference Teams Only through 01/10/2022
| Name | G | Att | Comp | Pct. | Yards | Yards/Att | TD | Int | Rating | Att/G | Yards/G | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Oklahoma State | 10 | 281 | 159 | 56.6 | 1734 | 6.2 | 10 | 7 | 115.18 | 28.1 | 173.4 |
| 2 | Iowa State | 11 | 296 | 182 | 61.5 | 2111 | 7.1 | 18 | 8 | 136.06 | 26.9 | 191.9 |
| 3 | Texas | 10 | 313 | 208 | 66.5 | 2278 | 7.3 | 15 | 7 | 138.93 | 31.3 | 227.8 |
| 3 | Baylor | 11 | 351 | 213 | 60.7 | 2574 | 7.3 | 11 | 16 | 123.50 | 31.9 | 234.0 |
| 5 | Kansas State | 11 | 308 | 214 | 69.5 | 2316 | 7.5 | 14 | 9 | 141.80 | 28.0 | 210.5 |
| 6 | West Virginia | 12 | 347 | 225 | 64.8 | 2690 | 7.8 | 17 | 9 | 140.94 | 28.9 | 224.2 |
| 7 | Oklahoma | 11 | 364 | 245 | 67.3 | 2984 | 8.2 | 23 | 10 | 151.53 | 33.1 | 271.3 |
| 8 | Texas Tech | 10 | 329 | 222 | 67.5 | 2779 | 8.4 | 24 | 5 | 159.46 | 32.9 | 277.9 |
| 9 | Kansas | 10 | 271 | 194 | 71.6 | 2494 | 9.2 | 25 | 7 | 174.17 | 27.1 | 249.4 |
| 10 | TCU | 10 | 268 | 178 | 66.4 | 2556 | 9.5 | 16 | 6 | 161.75 | 26.8 | 255.6 |