2021 Big 12 Conference Leaders Opponent First Downs - Games vs. Non-Conference Teams Only through 01/10/2022
| Name | G | Rush | Pass | Penalty | Total | Total/G | |
|---|---|---|---|---|---|---|---|
| 1 | TCU | 3 | 27 | 21 | 3 | 51 | 17.0 |
| 2 | Iowa State | 4 | 21 | 26 | 4 | 51 | 12.8 |
| 2 | Texas | 3 | 30 | 26 | 1 | 57 | 19.0 |
| 4 | West Virginia | 4 | 34 | 27 | 7 | 68 | 17.0 |
| 5 | Kansas State | 4 | 24 | 31 | 5 | 60 | 15.0 |
| 5 | Kansas | 3 | 32 | 31 | 5 | 68 | 22.7 |
| 7 | Baylor | 4 | 30 | 34 | 6 | 70 | 17.5 |
| 8 | Oklahoma | 4 | 28 | 45 | 6 | 79 | 19.8 |
| 9 | Texas Tech | 4 | 16 | 46 | 7 | 69 | 17.3 |
| 10 | Oklahoma State | 4 | 22 | 56 | 8 | 86 | 21.5 |