2021 Big 12 Conference Leaders Long Scrimmage Plays - Games vs. FBS Power 5 Conference Teams Only through 01/10/2022
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| Name | Team | Yr | Pos | G | Yards | Yards | Yards | Yards | Yards | Yards | Yards | Yards | Yards | |
| 1 | Breece Hall | Iowa State | JR | RB | 10 | 41 | 19 | 13 | 7 | 4 | 3 | 3 | 1 | 0 |
| 1 | Kendre Miller | TCU | SO | RB | 8 | 14 | 8 | 6 | 5 | 4 | 2 | 1 | 0 | 0 |
| 1 | Deuce Vaughn | Kansas St | SO | RB | 11 | 47 | 18 | 10 | 7 | 4 | 2 | 1 | 1 | 0 |
| 1 | Xavier Worthy | Texas | FR | WR | 10 | 27 | 13 | 8 | 5 | 4 | 3 | 1 | 0 | 0 |
| 5 | Marvin Mims | Oklahoma | SO | WR | 11 | 21 | 9 | 7 | 7 | 3 | 1 | 0 | 0 | 0 |
| 5 | Caleb Williams | Oklahoma | FR | QB | 9 | 12 | 7 | 5 | 5 | 3 | 2 | 1 | 0 | 0 |
| 7 | Taye Barber | TCU | SR | WR | 10 | 14 | 6 | 2 | 2 | 2 | 1 | 1 | 0 | 0 |
| 7 | Kaylon Geiger Sr. | Texas Tech | SR | WR | 10 | 16 | 7 | 5 | 3 | 2 | 1 | 1 | 0 | 0 |
| 7 | Quentin Johnston | TCU | SO | WR | 7 | 22 | 12 | 6 | 4 | 2 | 1 | 1 | 0 | 0 |
| 7 | Devin Neal | Kansas | FR | RB | 9 | 16 | 4 | 3 | 3 | 2 | 1 | 0 | 0 | 0 |
| 7 | Abram Smith | Baylor | SR | RB | 11 | 32 | 12 | 7 | 4 | 2 | 1 | 1 | 0 | 0 |
| 12 | Jerand Bradley | Texas Tech | FR | WR | 3 | 4 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 |
| 12 | Kennedy Brooks | Oklahoma | JR | RB | 11 | 31 | 15 | 6 | 3 | 1 | 1 | 0 | 0 | 0 |
| 12 | Phillip Brooks | Kansas St | JR | WR | 11 | 18 | 8 | 4 | 2 | 1 | 0 | 0 | 0 | 0 |
| 12 | Tahj Brooks | Texas Tech | SO | RB | 6 | 11 | 2 | 1 | 1 | 1 | 0 | 0 | 0 | 0 |
| 12 | Leddie Brown | WVU | SR | RB | 11 | 34 | 11 | 2 | 2 | 1 | 1 | 1 | 1 | 0 |
| 12 | Derius Davis | TCU | SR | WR | 10 | 21 | 8 | 5 | 4 | 1 | 1 | 0 | 0 | 0 |
| 12 | Trestan Ebner | Baylor | SR | RB | 11 | 23 | 7 | 4 | 1 | 1 | 1 | 0 | 0 | 0 |
| 12 | Isaiah Esdale | WVU | SR | WR | 9 | 13 | 4 | 2 | 1 | 1 | 0 | 0 | 0 | 0 |
| 12 | Drew Estrada | Baylor | SR | WR | 11 | 12 | 6 | 4 | 2 | 1 | 0 | 0 | 0 | 0 |
| 12 | Zach Evans | TCU | SO | RB | 4 | 17 | 7 | 3 | 1 | 1 | 0 | 0 | 0 | 0 |
| 12 | Loic Fouonji | Texas Tech | SO | WR | 7 | 3 | 2 | 2 | 2 | 1 | 1 | 0 | 0 | 0 |
| 12 | Keenan Garber | Kansas St | SO | WR | 9 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 |
| 12 | Garrett Greene | WVU | FR | QB | 10 | 8 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 |
| 12 | Jeremiah Hall | Oklahoma | SR | TE | 11 | 9 | 3 | 2 | 2 | 1 | 0 | 0 | 0 | 0 |
| 12 | Jadon Haselwood | Oklahoma | SO | WR | 10 | 12 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 |
| 12 | Will Howard | Kansas St | SO | QB | 4 | 2 | 2 | 2 | 1 | 1 | 1 | 1 | 0 | 0 |
| 12 | Xavier Hutchinson | Iowa State | SR | WR | 11 | 30 | 11 | 4 | 1 | 1 | 0 | 0 | 0 | 0 |
| 12 | Daniel Imatorbhebhe | Kansas St | SR | TE | 10 | 9 | 5 | 2 | 1 | 1 | 1 | 1 | 0 | 0 |
| 12 | Sam James | WVU | JR | WR | 12 | 17 | 6 | 5 | 2 | 1 | 0 | 0 | 0 | 0 |
| 12 | Malik Knowles | Kansas St | JR | WR | 11 | 18 | 5 | 3 | 2 | 1 | 1 | 0 | 0 | 0 |
| 12 | Travis Koontz | Texas Tech | SR | TE | 9 | 7 | 3 | 3 | 2 | 1 | 1 | 1 | 0 | 0 |
| 12 | Kwamie Lassiter II | Kansas | SR | WR | 10 | 21 | 7 | 1 | 1 | 1 | 1 | 0 | 0 | 0 |
| 12 | Tarique Milton | Iowa State | SR | WR | 10 | 8 | 4 | 3 | 2 | 1 | 1 | 0 | 0 | 0 |
| 12 | Jaden Nixon | Okla St | FR | RB | 2 | 2 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 |
| 12 | Bijan Robinson | Texas | SO | RB | 8 | 29 | 10 | 5 | 1 | 1 | 0 | 0 | 0 | 0 |
| 12 | R.J. Sneed | Baylor | SR | WR | 11 | 11 | 6 | 1 | 1 | 1 | 1 | 0 | 0 | 0 |
| 12 | SaRodorick Thompson | Texas Tech | JR | RB | 10 | 19 | 7 | 2 | 1 | 1 | 1 | 1 | 0 | 0 |
| 12 | Tyquan Thornton | Baylor | SR | WR | 11 | 30 | 11 | 5 | 5 | 1 | 1 | 1 | 0 | 0 |
| 12 | Jaylen Warren | Okla St | SR | RB | 10 | 28 | 9 | 2 | 2 | 1 | 0 | 0 | 0 | 0 |
| 12 | Marcus Washington | Texas | JR | WR | 10 | 11 | 6 | 1 | 1 | 1 | 0 | 0 | 0 | 0 |
| 12 | Trevon West | Oklahoma | SO | WR | 11 | 3 | 2 | 2 | 1 | 1 | 1 | 0 | 0 | 0 |
| 12 | Michael Woods II | Oklahoma | SR | WR | 9 | 15 | 3 | 2 | 1 | 1 | 0 | 0 | 0 | 0 |