2021 Big 12 Conference Leaders Long Scrimmage Plays - Games vs. FBS Teams With Winning Record Only through 01/10/2022
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| Name | Team | Yr | Pos | G | Yards | Yards | Yards | Yards | Yards | Yards | Yards | Yards | Yards | |
| 1 | Taye Barber | TCU | SR | WR | 7 | 14 | 6 | 3 | 3 | 3 | 2 | 1 | 0 | 0 |
| 1 | Kendre Miller | TCU | SO | RB | 5 | 10 | 7 | 5 | 4 | 3 | 2 | 1 | 0 | 0 |
| 1 | Xavier Worthy | Texas | FR | WR | 8 | 22 | 12 | 7 | 4 | 3 | 3 | 1 | 0 | 0 |
| 4 | Quentin Johnston | TCU | SO | WR | 5 | 12 | 8 | 4 | 2 | 2 | 1 | 1 | 0 | 0 |
| 4 | Marvin Mims | Oklahoma | SO | WR | 6 | 10 | 5 | 4 | 4 | 2 | 1 | 0 | 0 | 0 |
| 4 | Abram Smith | Baylor | SR | RB | 8 | 25 | 6 | 5 | 3 | 2 | 1 | 1 | 0 | 0 |
| 4 | Deuce Vaughn | Kansas St | SO | RB | 6 | 26 | 8 | 3 | 2 | 2 | 1 | 0 | 0 | 0 |
| 4 | Jaylen Warren | Okla St | SR | RB | 9 | 27 | 7 | 2 | 2 | 2 | 1 | 1 | 0 | 0 |
| 4 | Caleb Williams | Oklahoma | FR | QB | 6 | 5 | 2 | 2 | 2 | 2 | 1 | 1 | 0 | 0 |
| 10 | Jerand Bradley | Texas Tech | FR | WR | 1 | 2 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 |
| 10 | Tahj Brooks | Texas Tech | SO | RB | 7 | 13 | 4 | 3 | 3 | 1 | 0 | 0 | 0 | 0 |
| 10 | Derius Davis | TCU | SR | WR | 7 | 12 | 5 | 3 | 2 | 1 | 1 | 0 | 0 | 0 |
| 10 | Trestan Ebner | Baylor | SR | RB | 8 | 20 | 7 | 4 | 1 | 1 | 1 | 0 | 0 | 0 |
| 10 | Isaiah Esdale | WVU | SR | WR | 5 | 10 | 3 | 1 | 1 | 1 | 0 | 0 | 0 | 0 |
| 10 | Erik Ezukanma | Texas Tech | JR | WR | 6 | 19 | 9 | 6 | 2 | 1 | 0 | 0 | 0 | 0 |
| 10 | Keenan Garber | Kansas St | SO | WR | 5 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 |
| 10 | Breece Hall | Iowa State | JR | RB | 6 | 21 | 9 | 6 | 3 | 1 | 1 | 1 | 0 | 0 |
| 10 | Jeremiah Hall | Oklahoma | SR | TE | 6 | 5 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 |
| 10 | Jadon Haselwood | Oklahoma | SO | WR | 5 | 6 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 |
| 10 | Xavier Hutchinson | Iowa State | SR | WR | 7 | 15 | 5 | 2 | 1 | 1 | 0 | 0 | 0 | 0 |
| 10 | Daniel Imatorbhebhe | Kansas St | SR | TE | 5 | 5 | 3 | 2 | 1 | 1 | 1 | 0 | 0 | 0 |
| 10 | Sam James | WVU | JR | WR | 8 | 12 | 4 | 4 | 2 | 1 | 0 | 0 | 0 | 0 |
| 10 | Travis Koontz | Texas Tech | SR | TE | 6 | 7 | 3 | 3 | 2 | 1 | 1 | 1 | 0 | 0 |
| 10 | Bijan Robinson | Texas | SO | RB | 7 | 24 | 9 | 5 | 1 | 1 | 0 | 0 | 0 | 0 |
| 10 | Marcus Washington | Texas | JR | WR | 8 | 6 | 3 | 1 | 1 | 1 | 0 | 0 | 0 | 0 |