2021 Big 12 Conference Leaders Sacks - Games vs. FCS (I-AA) Teams Only through 01/10/2022
| Name | Team | Yr | Pos | G | Sacks | Sack Yards | Sacks/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Felix Anudike-Uzomah | Kansas St | SO | DE | 1 | 3.0 | 14 | 3.00 |
| 2 | Devin Harper | Okla St | SR | LB | 1 | 1.5 | 15 | 1.50 |
| 2 | Perrion Winfrey | Oklahoma | SR | DL | 1 | 1.5 | 5 | 1.50 |
| 4 | Ashton Logan | Baylor | SR | OLB | 1 | 1.0 | 13 | 1.00 |
| 4 | Isaiah Thomas | Oklahoma | SR | DL | 1 | 1.0 | 12 | 1.00 |
| 4 | Will McDonald IV | Iowa State | JR | DE | 1 | 1.0 | 10 | 1.00 |
| 4 | Khalid Duke | Kansas St | JR | DE | 1 | 1.0 | 10 | 1.00 |
| 4 | Akheem Mesidor | WVU | SO | DL | 1 | 1.0 | 10 | 1.00 |
| 4 | O'Rien Vance | Iowa State | SR | LB | 1 | 1.0 | 7 | 1.00 |
| 4 | Jahron McPherson | Kansas St | SR | DB | 1 | 1.0 | 7 | 1.00 |
| 4 | Kyron Johnson | Kansas | SR | DE | 1 | 1.0 | 7 | 1.00 |
| 4 | Mason Cobb | Okla St | SO | LB | 1 | 1.0 | 7 | 1.00 |
| 4 | Ochaun Mathis | TCU | JR | DE | 1 | 1.0 | 7 | 1.00 |
| 4 | Matt Jones | Baylor | SO | LB | 1 | 1.0 | 6 | 1.00 |
| 4 | Jaylon Hutchings | Texas Tech | JR | DL | 1 | 1.0 | 6 | 1.00 |
| 4 | Kamryn Farrar | Okla St | SO | LB | 1 | 1.0 | 5 | 1.00 |
| 4 | Krishon Merriweather | Texas Tech | SR | LB | 1 | 1.0 | 5 | 1.00 |
| 4 | Isaiah Coe | Oklahoma | JR | DL | 1 | 1.0 | 3 | 1.00 |
| 4 | Darel Middleton | WVU | JR | DL | 1 | 1.0 | 0 | 1.00 |
| 20 | Brock Martin | Okla St | SR | DE | 1 | 0.5 | 5 | 0.50 |
| 20 | Collin Oliver | Okla St | FR | DE | 1 | 0.5 | 5 | 0.50 |
| 20 | Jabbar Muhammad | Okla St | SO | CB | 1 | 0.5 | 4 | 0.50 |
| 20 | Reggie Grimes | Oklahoma | SO | DE | 1 | 0.5 | 4 | 0.50 |
Note: To qualify, player must have played in 75% of his team's games.