2021 Big 12 Conference Leaders Sacks - Games at Home Only through 01/10/2022
| Name | Team | Yr | Pos | G | Sacks | Sack Yards | Sacks/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Will McDonald IV | Iowa State | JR | DE | 6 | 8.0 | 50 | 1.33 |
| 2 | Felix Anudike-Uzomah | Kansas St | SO | DE | 7 | 8.0 | 38 | 1.14 |
| 3 | Eyioma Uwazurike | Iowa State | SR | DE | 6 | 5.5 | 49 | 0.92 |
| 4 | Isaiah Thomas | Oklahoma | SR | DL | 7 | 5.5 | 40 | 0.79 |
| 4 | Collin Oliver | Okla St | FR | DE | 7 | 5.5 | 28 | 0.79 |
| 6 | Perrion Winfrey | Oklahoma | SR | DL | 7 | 4.5 | 25 | 0.64 |
| 7 | Terrel Bernard | Baylor | SR | LB | 7 | 4.0 | 27 | 0.57 |
| 8 | TJ Franklin | Baylor | JR | DL | 7 | 3.5 | 20 | 0.50 |
| 8 | Nik Bonitto | Oklahoma | JR | OLB | 7 | 3.5 | 16 | 0.50 |
| 8 | Siaki Ika | Baylor | SO | DT | 6 | 3.0 | 21 | 0.50 |
| 8 | Jared Bartlett | WVU | SO | BAN | 6 | 3.0 | 19 | 0.50 |
| 8 | Dante Stills | WVU | SR | DL | 6 | 3.0 | 18 | 0.50 |
| 13 | Dylan Horton | TCU | SR | DE | 7 | 3.0 | 35 | 0.43 |
| 13 | Malcolm Rodriguez | Okla St | SR | LB | 7 | 3.0 | 20 | 0.43 |
| 13 | Daniel Green | Kansas St | JR | LB | 7 | 3.0 | 15 | 0.43 |
| 16 | Akheem Mesidor | WVU | SO | DL | 6 | 2.5 | 24 | 0.42 |
| 16 | Israel Antwine | Okla St | SR | DT | 6 | 2.5 | 8 | 0.42 |
| 18 | Nate Matlack | Kansas St | FR | DE | 7 | 2.5 | 25 | 0.36 |
| 18 | Jalen Pitre | Baylor | SR | S | 7 | 2.5 | 22 | 0.36 |
| 18 | Tyler Lacy | Okla St | JR | DE | 7 | 2.5 | 22 | 0.36 |
| 18 | Devin Harper | Okla St | SR | LB | 7 | 2.5 | 20 | 0.36 |
| 18 | Kamryn Farrar | Okla St | SO | LB | 7 | 2.5 | 9 | 0.36 |
| 23 | Taijh Alston | WVU | JR | DL | 6 | 2.0 | 18 | 0.33 |
| 23 | Kyron Johnson | Kansas | SR | DE | 6 | 2.0 | 17 | 0.33 |
| 23 | Tyree Wilson | Texas Tech | JR | DL | 6 | 2.0 | 14 | 0.33 |
| 23 | Ovie Oghoufo | Texas | JR | EDG | 6 | 2.0 | 7 | 0.33 |
| 27 | Matt Jones | Baylor | SO | LB | 7 | 2.0 | 17 | 0.29 |
| 27 | Timmy Horne | Kansas St | SR | DT | 7 | 2.0 | 9 | 0.29 |
| 27 | Gabe Hall | Baylor | SO | DL | 7 | 2.0 | 8 | 0.29 |
| 30 | Josh Chandler-Semedo | WVU | SR | LB | 6 | 1.5 | 11 | 0.25 |
| 30 | Jaylon Hutchings | Texas Tech | JR | DL | 6 | 1.5 | 8 | 0.25 |
| 32 | Reggie Grimes | Oklahoma | SO | DE | 7 | 1.5 | 18 | 0.21 |
| 32 | Bryson Jackson | Baylor | SR | OLB | 7 | 1.5 | 8 | 0.21 |
| 34 | Jett Bush | Texas | JR | LB | 5 | 1.0 | 9 | 0.20 |
| 34 | DeMarvion Overshown | Texas | SR | LB | 5 | 1.0 | 5 | 0.20 |
| 34 | Tucker Robertson | Iowa State | SR | DL | 5 | 1.0 | 2 | 0.20 |
| 37 | Malcolm Lee | Kansas | SR | DL | 6 | 1.0 | 20 | 0.17 |
| 37 | Rich Miller | Kansas | JR | LB | 6 | 1.0 | 14 | 0.17 |
| 37 | Jake Hummel | Iowa State | SR | LB | 6 | 1.0 | 11 | 0.17 |
| 37 | Caleb Sampson | Kansas | SR | DL | 6 | 1.0 | 11 | 0.17 |
| 37 | Blake Peterson | Iowa State | SO | DE | 6 | 1.0 | 9 | 0.17 |
| 37 | Nook Bradford | TCU | JR | S | 6 | 1.0 | 9 | 0.17 |
| 37 | Alfred Collins | Texas | SO | DL | 6 | 1.0 | 8 | 0.17 |
| 37 | Isaiah Lee | Iowa State | JR | DT | 6 | 1.0 | 7 | 0.17 |
| 37 | Keondre Coburn | Texas | JR | DL | 6 | 1.0 | 7 | 0.17 |
| 37 | Ray Thornton | Texas | SR | EDG | 6 | 1.0 | 6 | 0.17 |
| 37 | Alonzo Addae | WVU | SR | S | 6 | 1.0 | 6 | 0.17 |
| 37 | Krishon Merriweather | Texas Tech | SR | LB | 6 | 1.0 | 5 | 0.17 |
| 37 | Byron Murphy II | Texas | FR | DL | 6 | 1.0 | 5 | 0.17 |
| 37 | Garmon Randolph | Baylor | SO | OLB | 6 | 1.0 | 4 | 0.17 |
Note: To qualify, player must have played in 75% of his team's games.