2021 Big 12 Conference Leaders Sacks - Games on the Road/Neutral Site Only through 01/10/2022
| Name | Team | Yr | Pos | G | Sacks | Sack Yards | Sacks/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Brock Martin | Okla St | SR | DE | 7 | 8.5 | 51 | 1.21 |
| 2 | Kyron Johnson | Kansas | SR | DE | 6 | 4.5 | 18 | 0.75 |
| 3 | Collin Oliver | Okla St | FR | DE | 7 | 5.0 | 46 | 0.71 |
| 3 | Tyree Wilson | Texas Tech | JR | DL | 7 | 5.0 | 44 | 0.71 |
| 5 | Nik Bonitto | Oklahoma | JR | OLB | 5 | 3.5 | 23 | 0.70 |
| 6 | Gabe Hall | Baylor | SO | DL | 6 | 4.0 | 15 | 0.67 |
| 7 | Ochaun Mathis | TCU | JR | DE | 5 | 3.0 | 21 | 0.60 |
| 8 | Terrel Bernard | Baylor | SR | LB | 6 | 3.5 | 26 | 0.58 |
| 9 | Dante Stills | WVU | SR | DL | 7 | 4.0 | 34 | 0.57 |
| 10 | Will McDonald IV | Iowa State | JR | DE | 7 | 3.5 | 27 | 0.50 |
| 10 | Eyioma Uwazurike | Iowa State | SR | DE | 7 | 3.5 | 25 | 0.50 |
| 10 | Devin Harper | Okla St | SR | LB | 7 | 3.5 | 25 | 0.50 |
| 10 | Felix Anudike-Uzomah | Kansas St | SO | DE | 6 | 3.0 | 14 | 0.50 |
| 10 | Isaiah Thomas | Oklahoma | SR | DL | 5 | 2.5 | 16 | 0.50 |
| 15 | Taijh Alston | WVU | JR | DL | 7 | 3.0 | 8 | 0.43 |
| 16 | Ben Davis | Texas | SR | EDG | 5 | 2.0 | 17 | 0.40 |
| 17 | Brendon Evers | Okla St | SR | DT | 7 | 2.5 | 10 | 0.36 |
| 18 | Eli Huggins | Kansas St | SR | DT | 6 | 2.0 | 7 | 0.33 |
| 19 | Jason Taylor II | Okla St | JR | S | 7 | 2.0 | 37 | 0.29 |
| 19 | Jaylon Hutchings | Texas Tech | JR | DL | 7 | 2.0 | 19 | 0.29 |
| 19 | Bryson Jackson | Baylor | SR | OLB | 7 | 2.0 | 18 | 0.29 |
| 19 | Akheem Mesidor | WVU | SO | DL | 7 | 2.0 | 14 | 0.29 |
| 19 | Brayden Utley | Baylor | JR | DL | 7 | 2.0 | 13 | 0.29 |
| 19 | Jayden Jernigan | Okla St | SO | DT | 7 | 2.0 | 13 | 0.29 |
| 19 | Colin Schooler | Texas Tech | SR | LB | 7 | 2.0 | 7 | 0.29 |
| 26 | Gerry Vaughn | Iowa State | JR | LB | 7 | 1.5 | 9 | 0.21 |
| 26 | Cole Maxwell | Baylor | SR | DT | 7 | 1.5 | 7 | 0.21 |
| 28 | Jamoi Hodge | TCU | SO | LB | 5 | 1.0 | 8 | 0.20 |
| 28 | Khari Coleman | TCU | SO | DE | 5 | 1.0 | 7 | 0.20 |
| 28 | Danny Stutsman | Oklahoma | FR | LB | 5 | 1.0 | 6 | 0.20 |
| 28 | Marcus Stripling | Oklahoma | JR | DE | 5 | 1.0 | 5 | 0.20 |
| 28 | Perrion Winfrey | Oklahoma | SR | DL | 5 | 1.0 | 4 | 0.20 |
| 28 | Jereme Robinson | Kansas | SO | DL | 5 | 1.0 | 2 | 0.20 |
| 28 | Dylan Horton | TCU | SR | DE | 5 | 1.0 | 2 | 0.20 |
| 35 | Anthony Cook | Texas | SR | DB | 6 | 1.0 | 16 | 0.17 |
| 35 | DeMarvion Overshown | Texas | SR | LB | 6 | 1.0 | 9 | 0.17 |
| 35 | Cody Fletcher | Kansas St | SR | LB | 6 | 1.0 | 7 | 0.17 |
| 35 | Nate Betts | Kansas | SR | LB | 6 | 1.0 | 7 | 0.17 |
| 35 | Alfred Collins | Texas | SO | DL | 6 | 1.0 | 7 | 0.17 |
| 35 | Nate Matlack | Kansas St | FR | DE | 6 | 1.0 | 6 | 0.17 |
| 35 | T'Vondre Sweat | Texas | JR | DL | 6 | 1.0 | 4 | 0.17 |
| 35 | Byron Murphy II | Texas | FR | DL | 6 | 1.0 | 1 | 0.17 |
| 43 | Blake Peterson | Iowa State | SO | DE | 7 | 1.0 | 11 | 0.14 |
| 43 | Jarrick Bernard-Converse | Okla St | SR | CB | 7 | 1.0 | 11 | 0.14 |
| 43 | Josh Landry | Baylor | JR | DT | 7 | 1.0 | 10 | 0.14 |
| 43 | Tyler Lacy | Okla St | JR | DE | 7 | 1.0 | 10 | 0.14 |
| 43 | Jackie Matthews | WVU | JR | CB | 7 | 1.0 | 10 | 0.14 |
| 43 | Siaki Ika | Baylor | SO | DT | 7 | 1.0 | 7 | 0.14 |
| 43 | Lamont Bishop | Okla St | JR | LB | 7 | 1.0 | 7 | 0.14 |
| 43 | Kody Walterscheid | Okla St | SO | DE | 7 | 1.0 | 7 | 0.14 |
Note: To qualify, player must have played in 75% of his team's games.