2021 Big 12 Conference Leaders Passing - Games in December/January Only through 01/10/2022
| Name | Team | Yr | Pos | G | Att | Comp | Pct. | Yards | Yards/Att | TD | Int | Rating | Att/G | Yards/G | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Spencer Sanders | Okla St | JR | QB | 2 | 97 | 65 | 67.0 | 628 | 6.5 | 4 | 4 | 126.75 | 48.5 | 314.0 |
| 2 | Skylar Thompson | Kansas St | SR | QB | 1 | 28 | 21 | 75.0 | 259 | 9.3 | 3 | 0 | 188.06 | 28.0 | 259.0 |
| 2 | Caleb Williams | Oklahoma | FR | QB | 1 | 27 | 21 | 77.8 | 242 | 9.0 | 3 | 0 | 189.74 | 27.0 | 242.0 |
| 2 | Blake Shapen | Baylor | FR | QB | 1 | 28 | 23 | 82.1 | 180 | 6.4 | 3 | 0 | 171.50 | 28.0 | 180.0 |
| 5 | Donovan Smith | Texas Tech | FR | QB | 1 | 28 | 15 | 53.6 | 252 | 9.0 | 1 | 0 | 140.95 | 28.0 | 252.0 |
| 5 | Brock Purdy | Iowa State | SR | QB | 1 | 39 | 23 | 59.0 | 204 | 5.2 | 1 | 1 | 106.24 | 39.0 | 204.0 |
| 5 | Gerry Bohanon | Baylor | JR | QB | 1 | 17 | 7 | 41.2 | 40 | 2.4 | 1 | 1 | 68.60 | 17.0 | 40.0 |