2021 Big 12 Conference Leaders Yards From Scrimmage - Games in November Only through 01/10/2022
| Name | Team | Yr | Pos | G | Rush Yards | Recv Yards | TD | Plays | Total Yards | Yards/Play | Yards/G | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Derius Davis | TCU | SR | WR | 4 | 57 | 246 | 1 | 22 | 303 | 13.8 | 75.8 |
| 2 | Tay Martin | Okla St | SR | WR | 4 | 13 | 325 | 4 | 27 | 338 | 12.5 | 84.5 |
| 3 | Charlie Kolar | Iowa State | SR | TE | 4 | 0 | 365 | 3 | 30 | 365 | 12.2 | 91.3 |
| 4 | Xavier Hutchinson | Iowa State | SR | WR | 4 | 10 | 363 | 0 | 31 | 373 | 12.0 | 93.3 |
| 5 | Xavier Worthy | Texas | FR | WR | 4 | 0 | 324 | 5 | 29 | 324 | 11.2 | 81.0 |
| 6 | Kwamie Lassiter II | Kansas | SR | WR | 4 | 0 | 296 | 2 | 29 | 296 | 10.2 | 74.0 |
| 7 | Deuce Vaughn | Kansas St | SO | RB | 4 | 554 | 120 | 6 | 86 | 674 | 7.8 | 168.5 |
| 8 | Breece Hall | Iowa State | JR | RB | 4 | 487 | 94 | 10 | 84 | 581 | 6.9 | 145.3 |
| 8 | Keilan Robinson | Texas | JR | RB | 3 | 146 | 20 | 1 | 24 | 166 | 6.9 | 55.3 |
| 10 | Dominic Richardson | Okla St | SO | RB | 4 | 221 | 20 | 2 | 38 | 241 | 6.3 | 60.3 |
| 11 | Kennedy Brooks | Oklahoma | JR | RB | 3 | 309 | 34 | 1 | 55 | 343 | 6.2 | 114.3 |
| 11 | Gerry Bohanon | Baylor | JR | QB | 3 | 142 | 0 | 2 | 23 | 142 | 6.2 | 47.3 |
| 13 | Trestan Ebner | Baylor | SR | RB | 4 | 184 | 173 | 3 | 63 | 357 | 5.7 | 89.3 |
| 14 | Roschon Johnson | Texas | JR | RB | 4 | 312 | 33 | 2 | 62 | 345 | 5.6 | 86.3 |
| 15 | Tahj Brooks | Texas Tech | SO | RB | 3 | 121 | 40 | 2 | 30 | 161 | 5.4 | 53.7 |
| 15 | Jaylin Noel | Iowa State | FR | WR | 4 | 0 | 108 | 0 | 20 | 108 | 5.4 | 27.0 |
| 17 | Leddie Brown | WVU | SR | RB | 4 | 423 | 62 | 2 | 95 | 485 | 5.1 | 121.3 |
| 17 | Abram Smith | Baylor | SR | RB | 4 | 436 | 39 | 1 | 94 | 475 | 5.1 | 118.8 |
| 17 | Devin Neal | Kansas | FR | RB | 3 | 264 | 52 | 5 | 62 | 316 | 5.1 | 105.3 |
| 17 | Emari Demercado | TCU | SR | RB | 4 | 303 | 84 | 2 | 76 | 387 | 5.1 | 96.8 |
| 17 | Joe Ervin | Kansas St | SO | RB | 3 | 96 | 12 | 1 | 21 | 108 | 5.1 | 36.0 |
| 22 | Spencer Sanders | Okla St | JR | QB | 4 | 212 | 0 | 2 | 42 | 212 | 5.0 | 53.0 |
| 22 | Tony Mathis Jr. | WVU | SO | RB | 4 | 169 | 5 | 0 | 35 | 174 | 5.0 | 43.5 |
| 22 | SaRodorick Thompson | Texas Tech | JR | RB | 3 | 74 | 6 | 1 | 16 | 80 | 5.0 | 26.7 |
| 25 | Jaylen Warren | Okla St | SR | RB | 4 | 284 | 43 | 5 | 68 | 327 | 4.8 | 81.8 |
| 26 | Dezmon Jackson | Okla St | SR | RB | 3 | 88 | 0 | 2 | 23 | 88 | 3.8 | 29.3 |
| 27 | Amauri Pesek-Hickson | Kansas | FR | RB | 4 | 126 | 1 | 0 | 35 | 127 | 3.6 | 31.8 |
| 28 | Jalon Daniels | Kansas | SO | QB | 4 | 94 | 0 | 3 | 31 | 94 | 3.0 | 23.5 |
| 29 | Caleb Williams | Oklahoma | FR | QB | 3 | 120 | 0 | 2 | 41 | 120 | 2.9 | 40.0 |
| 30 | Donovan Smith | Texas Tech | FR | QB | 3 | 31 | 0 | 0 | 29 | 31 | 1.1 | 10.3 |
| 31 | Brock Purdy | Iowa State | SR | QB | 4 | 19 | 0 | 0 | 26 | 19 | 0.7 | 4.8 |
| 32 | Jarret Doege | WVU | SR | QB | 4 | -75 | 0 | 0 | 24 | -75 | -3.1 | -18.8 |
Note: To qualify, player must have played in 75% of his team's games and have a minimum of 5.0 plays per game played.