2021 Big 12 Conference Leaders Yards From Scrimmage - Games vs. Unranked Teams Only (AP Poll) through 01/10/2022
| Name | Team | Yr | Pos | G | Rush Yards | Recv Yards | TD | Plays | Total Yards | Yards/Play | Yards/G | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Tay Martin | Okla St | SR | WR | 9 | 9 | 655 | 6 | 49 | 664 | 13.6 | 73.8 |
| 1 | Erik Ezukanma | Texas Tech | JR | WR | 7 | 106 | 383 | 5 | 36 | 489 | 13.6 | 69.9 |
| 3 | Xavier Hutchinson | Iowa State | SR | WR | 8 | 8 | 716 | 3 | 57 | 724 | 12.7 | 90.5 |
| 4 | Xavier Worthy | Texas | FR | WR | 7 | 0 | 502 | 9 | 41 | 502 | 12.2 | 71.7 |
| 5 | Kwamie Lassiter II | Kansas | SR | WR | 9 | 0 | 528 | 3 | 48 | 528 | 11.0 | 58.7 |
| 6 | Keilan Robinson | Texas | JR | RB | 6 | 271 | 33 | 3 | 35 | 304 | 8.7 | 50.7 |
| 7 | Kendre Miller | TCU | SO | RB | 8 | 570 | 61 | 7 | 74 | 631 | 8.5 | 78.9 |
| 8 | Caleb Williams | Oklahoma | FR | QB | 8 | 348 | 0 | 5 | 43 | 348 | 8.1 | 43.5 |
| 9 | Trestan Ebner | Baylor | SR | RB | 9 | 610 | 222 | 4 | 125 | 832 | 6.7 | 92.4 |
| 10 | Breece Hall | Iowa State | JR | RB | 8 | 1085 | 173 | 17 | 192 | 1258 | 6.6 | 157.3 |
| 11 | Deuce Vaughn | Kansas St | SO | RB | 10 | 1203 | 254 | 19 | 225 | 1457 | 6.5 | 145.7 |
| 12 | Roschon Johnson | Texas | JR | RB | 7 | 510 | 41 | 5 | 86 | 551 | 6.4 | 78.7 |
| 13 | Kennedy Brooks | Oklahoma | JR | RB | 10 | 917 | 24 | 9 | 153 | 941 | 6.2 | 94.1 |
| 14 | Eric Gray | Oklahoma | JR | RB | 10 | 326 | 189 | 3 | 85 | 515 | 6.1 | 51.5 |
| 15 | Abram Smith | Baylor | SR | RB | 9 | 933 | 55 | 8 | 168 | 988 | 5.9 | 109.8 |
| 15 | Dominic Richardson | Okla St | SO | RB | 10 | 343 | 54 | 3 | 67 | 397 | 5.9 | 39.7 |
| 17 | Xavier White | Texas Tech | JR | RB | 9 | 244 | 107 | 2 | 61 | 351 | 5.8 | 39.0 |
| 18 | Jaylen Warren | Okla St | SR | RB | 10 | 953 | 159 | 8 | 198 | 1112 | 5.6 | 111.2 |
| 18 | SaRodorick Thompson | Texas Tech | JR | RB | 8 | 458 | 113 | 10 | 102 | 571 | 5.6 | 71.4 |
| 18 | Brock Purdy | Iowa State | SR | QB | 8 | 265 | 0 | 1 | 47 | 265 | 5.6 | 33.1 |
| 21 | Leddie Brown | WVU | SR | RB | 9 | 941 | 203 | 14 | 216 | 1144 | 5.3 | 127.1 |
| 22 | Devin Neal | Kansas | FR | RB | 8 | 549 | 59 | 7 | 122 | 608 | 5.0 | 76.0 |
| 23 | Jason Bean | Kansas | JR | QB | 8 | 255 | -1 | 2 | 58 | 254 | 4.4 | 31.8 |
| 24 | Tony Mathis Jr. | WVU | SO | RB | 8 | 287 | 29 | 0 | 74 | 316 | 4.3 | 39.5 |
| 24 | Emari Demercado | TCU | SR | RB | 8 | 240 | 31 | 3 | 63 | 271 | 4.3 | 33.9 |
| 26 | Amauri Pesek-Hickson | Kansas | FR | RB | 8 | 189 | 34 | 0 | 56 | 223 | 4.0 | 27.9 |
| 27 | Spencer Sanders | Okla St | JR | QB | 9 | 341 | 0 | 5 | 88 | 341 | 3.9 | 37.9 |
| 28 | Gerry Bohanon | Baylor | JR | QB | 8 | 173 | -5 | 6 | 50 | 168 | 3.4 | 21.0 |
| 29 | Max Duggan | TCU | JR | QB | 9 | 307 | 0 | 3 | 97 | 307 | 3.2 | 34.1 |
| 30 | Spencer Rattler | Oklahoma | SO | QB | 8 | 86 | 0 | 3 | 40 | 86 | 2.2 | 10.8 |
Note: To qualify, player must have played in 75% of his team's games and have a minimum of 5.0 plays per game played.