2021 Conference USA Leaders Passes Defended - Games vs. FBS Power 5 Conference Teams Only through 01/10/2022
| Name | G | Int. | Passes Broken Up | Passes Defended | Passes Defended/G | |
|---|---|---|---|---|---|---|
| 1 | Western Kentucky | 2 | 0 | 7 | 7 | 3.50 |
| 2 | Florida Atlantic | 1 | 2 | 4 | 6 | 6.00 |
| 3 | UTSA | 1 | 0 | 5 | 5 | 5.00 |
| 3 | Rice | 2 | 2 | 3 | 5 | 2.50 |
| 3 | Louisiana Tech | 2 | 1 | 4 | 5 | 2.50 |
| 3 | Charlotte | 2 | 0 | 5 | 5 | 2.50 |
| 7 | UAB | 1 | 1 | 2 | 3 | 3.00 |
| 7 | Florida International | 1 | 0 | 3 | 3 | 3.00 |
| 9 | Old Dominion | 1 | 0 | 2 | 2 | 2.00 |
| 10 | Southern Mississippi | 1 | 1 | 0 | 1 | 1.00 |
| 10 | Middle Tennessee | 1 | 0 | 1 | 1 | 1.00 |
| 10 | North Texas | 1 | 0 | 1 | 1 | 1.00 |