2021 Conference USA Leaders Passes Defended - Games vs. Conference Teams Only through 01/10/2022
| Name | G | Int. | Passes Broken Up | Passes Defended | Passes Defended/G | |
|---|---|---|---|---|---|---|
| 1 | Western Kentucky | 9 | 18 | 44 | 62 | 6.89 |
| 2 | Middle Tennessee State | 8 | 10 | 36 | 46 | 5.75 |
| 3 | Florida Atlantic | 8 | 8 | 36 | 44 | 5.50 |
| 4 | Rice | 8 | 11 | 32 | 43 | 5.38 |
| 4 | Old Dominion | 8 | 7 | 36 | 43 | 5.38 |
| 6 | UTEP | 8 | 6 | 35 | 41 | 5.13 |
| 7 | UTSA | 9 | 10 | 30 | 40 | 4.44 |
| 8 | UAB | 8 | 7 | 27 | 34 | 4.25 |
| 8 | Marshall | 8 | 7 | 27 | 34 | 4.25 |
| 10 | Southern Miss | 8 | 9 | 23 | 32 | 4.00 |
| 11 | North Texas | 8 | 3 | 24 | 27 | 3.38 |
| 12 | Louisiana Tech | 8 | 6 | 20 | 26 | 3.25 |
| 13 | Charlotte | 8 | 7 | 18 | 25 | 3.13 |
| 14 | FIU | 8 | 2 | 14 | 16 | 2.00 |