2021 Conference USA Leaders Rushing Offense - Games vs. FBS Power 5 Conference Teams Only through 01/10/2022
| Name | G | Att | Yards | Avg. | TD | Att/G | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | UTSA | 1 | 50 | 217 | 4.34 | 3 | 50.00 | 217.00 |
| 2 | North Texas | 1 | 49 | 188 | 3.84 | 1 | 49.00 | 188.00 |
| 3 | Old Dominion | 1 | 39 | 145 | 3.72 | 0 | 39.00 | 145.00 |
| 4 | UAB | 1 | 36 | 127 | 3.53 | 0 | 36.00 | 127.00 |
| 5 | Louisiana Tech | 2 | 60 | 240 | 4.00 | 1 | 30.00 | 120.00 |
| 6 | Charlotte | 2 | 66 | 232 | 3.52 | 1 | 33.00 | 116.00 |
| 7 | Rice | 2 | 71 | 225 | 3.17 | 1 | 35.50 | 112.50 |
| 8 | Florida Atlantic | 1 | 37 | 92 | 2.49 | 1 | 37.00 | 92.00 |
| 9 | Western Kentucky | 2 | 46 | 165 | 3.59 | 1 | 23.00 | 82.50 |
| 10 | Southern Mississippi | 1 | 33 | 82 | 2.48 | 0 | 33.00 | 82.00 |
| 11 | Middle Tennessee | 1 | 36 | 66 | 1.83 | 0 | 36.00 | 66.00 |
| 12 | Florida International | 1 | 29 | 55 | 1.90 | 1 | 29.00 | 55.00 |