2021 Conference USA Leaders Rushing Offense - Games vs. Ranked Teams Only (AP Poll) through 01/10/2022
| Name | G | Att | Yards | Avg. | TD | Att/G | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Marshall | 1 | 30 | 187 | 6.23 | 3 | 30.00 | 187.00 |
| 2 | UAB | 2 | 79 | 350 | 4.43 | 1 | 39.50 | 175.00 |
| 3 | Old Dominion | 1 | 39 | 145 | 3.72 | 0 | 39.00 | 145.00 |
| 4 | Louisiana Tech | 1 | 35 | 139 | 3.97 | 0 | 35.00 | 139.00 |
| 5 | UTSA | 1 | 24 | 117 | 4.88 | 1 | 24.00 | 117.00 |
| 6 | Rice | 2 | 75 | 207 | 2.76 | 1 | 37.50 | 103.50 |
| 7 | Southern Mississippi | 1 | 33 | 82 | 2.48 | 0 | 33.00 | 82.00 |
| 8 | Western Kentucky | 1 | 26 | 72 | 2.77 | 0 | 26.00 | 72.00 |