2021 Conference USA Leaders Passes Defended - Games vs. FBS (I-A) Teams Only through 01/10/2022
| Name | G | Int. | Passes Broken Up | Passes Defended | Passes Defended/G | |
|---|---|---|---|---|---|---|
| 1 | Middle Tennessee | 12 | 16 | 56 | 72 | 6.00 |
| 2 | Western Kentucky | 13 | 20 | 57 | 77 | 5.92 |
| 3 | Florida Atlantic | 11 | 11 | 44 | 55 | 5.00 |
| 4 | Rice | 11 | 13 | 40 | 53 | 4.82 |
| 5 | UTEP | 12 | 7 | 50 | 57 | 4.75 |
| 6 | Old Dominion | 12 | 7 | 45 | 52 | 4.33 |
| 7 | Marshall | 12 | 10 | 40 | 50 | 4.17 |
| 8 | UAB | 12 | 10 | 38 | 48 | 4.00 |
| 9 | UTSA | 13 | 12 | 39 | 51 | 3.92 |
| 10 | Southern Mississippi | 11 | 10 | 30 | 40 | 3.64 |
| 11 | Louisiana Tech | 11 | 7 | 27 | 34 | 3.09 |
| 12 | Charlotte | 11 | 8 | 24 | 32 | 2.91 |
| 13 | North Texas | 12 | 5 | 28 | 33 | 2.75 |
| 14 | Florida International | 11 | 3 | 26 | 29 | 2.64 |