2021 Conference USA Leaders Opponent Penalties - Games vs. FBS non-Power 5 Conference Teams Only through 01/10/2022
| Name | G | Pen. | Yards | Pen./G | Yards/G | |
|---|---|---|---|---|---|---|
| 1 | Old Dominion | 11 | 91 | 823 | 8.3 | 74.8 |
| 2 | Louisiana Tech | 9 | 63 | 630 | 7.0 | 70.0 |
| 3 | Charlotte | 9 | 73 | 623 | 8.1 | 69.2 |
| 4 | UTSA | 12 | 99 | 800 | 8.3 | 66.7 |
| 5 | Rice | 9 | 58 | 596 | 6.4 | 66.2 |
| 6 | North Texas | 11 | 82 | 716 | 7.5 | 65.1 |
| 7 | UTEP | 12 | 81 | 778 | 6.8 | 64.8 |
| 8 | Florida Atlantic | 10 | 74 | 643 | 7.4 | 64.3 |
| 9 | Western Kentucky | 11 | 81 | 700 | 7.4 | 63.6 |
| 10 | Southern Miss | 10 | 70 | 635 | 7.0 | 63.5 |
| 11 | Middle Tennessee State | 11 | 76 | 635 | 6.9 | 57.7 |
| 12 | Marshall | 12 | 72 | 668 | 6.0 | 55.7 |
| 13 | UAB | 11 | 63 | 538 | 5.7 | 48.9 |
| 14 | FIU | 10 | 48 | 468 | 4.8 | 46.8 |