2021 Conference USA Leaders Opponent Penalties - Games vs. FBS Power 5 Conference Teams Only through 01/10/2022
| Name | G | Pen. | Yards | Pen./G | Yards/G | |
|---|---|---|---|---|---|---|
| 1 | Florida Atlantic | 1 | 9 | 91 | 9.0 | 91.0 |
| 2 | Florida International | 1 | 9 | 75 | 9.0 | 75.0 |
| 3 | Louisiana Tech | 2 | 16 | 145 | 8.0 | 72.5 |
| 4 | North Texas | 1 | 7 | 65 | 7.0 | 65.0 |
| 5 | Rice | 2 | 15 | 129 | 7.5 | 64.5 |
| 6 | Southern Mississippi | 1 | 7 | 62 | 7.0 | 62.0 |
| 7 | UTSA | 1 | 7 | 61 | 7.0 | 61.0 |
| 8 | Charlotte | 2 | 12 | 120 | 6.0 | 60.0 |
| 9 | UAB | 1 | 4 | 47 | 4.0 | 47.0 |
| 10 | Western Kentucky | 2 | 10 | 80 | 5.0 | 40.0 |
| 11 | Old Dominion | 1 | 2 | 20 | 2.0 | 20.0 |
| 12 | Middle Tennessee | 1 | 3 | 16 | 3.0 | 16.0 |