2021 Conference USA Leaders Opponent Penalties - Games vs. Ranked Teams Only (AP Poll) through 01/10/2022
| Name | G | Pen. | Yards | Pen./G | Yards/G | |
|---|---|---|---|---|---|---|
| 1 | UTSA | 1 | 14 | 124 | 14.0 | 124.0 |
| 2 | Rice | 2 | 20 | 206 | 10.0 | 103.0 |
| 3 | Southern Mississippi | 1 | 7 | 62 | 7.0 | 62.0 |
| 4 | Western Kentucky | 1 | 6 | 60 | 6.0 | 60.0 |
| 5 | Marshall | 1 | 6 | 50 | 6.0 | 50.0 |
| 6 | Louisiana Tech | 1 | 4 | 49 | 4.0 | 49.0 |
| 7 | UAB | 2 | 6 | 57 | 3.0 | 28.5 |
| 8 | Old Dominion | 1 | 2 | 20 | 2.0 | 20.0 |