2021 Conference USA Leaders Sacks Allowed - Games vs. FBS Power 5 Conference Teams Only through 01/10/2022
| Name | G | Sacks | Sack Yards | Sacks/G | |
|---|---|---|---|---|---|
| 1 | UTSA | 1 | 1.0 | 6 | 1.00 |
| 2 | Old Dominion | 1 | 2.0 | 5 | 2.00 |
| 2 | FIU | 1 | 2.0 | 16 | 2.00 |
| 2 | Southern Miss | 1 | 2.0 | 19 | 2.00 |
| 5 | North Texas | 1 | 3.0 | 18 | 3.00 |
| 5 | Middle Tennessee State | 1 | 3.0 | 20 | 3.00 |
| 5 | UAB | 1 | 3.0 | 21 | 3.00 |
| 8 | Louisiana Tech | 2 | 4.0 | 26 | 2.00 |
| 8 | Charlotte | 2 | 4.0 | 26 | 2.00 |
| 8 | Western Kentucky | 2 | 4.0 | 30 | 2.00 |
| 11 | Rice | 2 | 5.0 | 19 | 2.50 |
| 12 | Florida Atlantic | 1 | 6.0 | 36 | 6.00 |