2021 Conference USA Leaders Total Defense - Games vs. FBS (I-A) Teams Only through 01/10/2022
| Name | G | Rush Yards | Pass Yards | Plays | Total Yards | Yards/Play | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | UAB | 12 | 1379 | 2739 | 801 | 4118 | 5.14 | 343.2 |
| 2 | UTEP | 12 | 1687 | 2515 | 822 | 4202 | 5.11 | 350.2 |
| 3 | Southern Mississippi | 11 | 1806 | 2335 | 684 | 4141 | 6.05 | 376.5 |
| 4 | North Texas | 12 | 1762 | 2786 | 800 | 4548 | 5.69 | 379.0 |
| 5 | Middle Tennessee | 12 | 1680 | 2889 | 861 | 4569 | 5.31 | 380.8 |
| 6 | UTSA | 13 | 1517 | 3579 | 875 | 5096 | 5.82 | 392.0 |
| 7 | Old Dominion | 12 | 1640 | 3178 | 883 | 4818 | 5.46 | 401.5 |
| 8 | Marshall | 12 | 2425 | 2554 | 943 | 4979 | 5.28 | 414.9 |
| 9 | Louisiana Tech | 11 | 1895 | 2719 | 769 | 4614 | 6.00 | 419.5 |
| 10 | Florida Atlantic | 11 | 1857 | 2762 | 784 | 4619 | 5.89 | 419.9 |
| 11 | Rice | 11 | 1850 | 2930 | 712 | 4780 | 6.71 | 434.5 |
| 12 | Western Kentucky | 13 | 2157 | 3558 | 1006 | 5715 | 5.68 | 439.6 |
| 13 | Charlotte | 11 | 2282 | 3080 | 720 | 5362 | 7.45 | 487.5 |
| 14 | Florida International | 11 | 2662 | 2959 | 815 | 5621 | 6.90 | 511.0 |