2021 Conference USA Leaders Total Defense - All Games through 01/10/2022
| Name | G | Rush Yards | Pass Yards | Plays | Total Yards | Yards/Play | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | UAB | 13 | 1449 | 2825 | 851 | 4274 | 5.02 | 328.8 |
| 2 | UTEP | 13 | 1805 | 2730 | 869 | 4535 | 5.22 | 348.8 |
| 3 | Southern Mississippi | 12 | 1868 | 2425 | 743 | 4293 | 5.78 | 357.8 |
| 4 | Middle Tennessee | 13 | 1768 | 3075 | 941 | 4843 | 5.15 | 372.5 |
| 5 | UTSA | 14 | 1606 | 3612 | 924 | 5218 | 5.65 | 372.7 |
| 6 | North Texas | 13 | 1976 | 2990 | 875 | 4966 | 5.68 | 382.0 |
| 7 | Old Dominion | 13 | 1744 | 3261 | 939 | 5005 | 5.33 | 385.0 |
| 8 | Marshall | 13 | 2496 | 2660 | 1003 | 5156 | 5.14 | 396.6 |
| 9 | Florida Atlantic | 12 | 1886 | 2970 | 842 | 4856 | 5.77 | 404.7 |
| 10 | Louisiana Tech | 12 | 1998 | 3214 | 855 | 5212 | 6.10 | 434.3 |
| 11 | Rice | 12 | 1944 | 3287 | 782 | 5231 | 6.69 | 435.9 |
| 12 | Western Kentucky | 14 | 2358 | 3753 | 1083 | 6111 | 5.64 | 436.5 |
| 13 | Charlotte | 12 | 2446 | 3130 | 782 | 5576 | 7.13 | 464.7 |
| 14 | Florida International | 12 | 2758 | 3154 | 882 | 5912 | 6.70 | 492.7 |