2021 Conference USA Leaders Scoring Defense - Games in August/September Only through 01/10/2022
| Name | G | TD | FG | 1XP | 2XP | Safety | Points | Points/G | |
|---|---|---|---|---|---|---|---|---|---|
| 1 | UAB | 4 | 12 | 0 | 11 | 0 | 0 | 83 | 20.8 |
| 2 | Florida Atlantic | 4 | 12 | 1 | 11 | 0 | 0 | 86 | 21.5 |
| 2 | Southern Mississippi | 4 | 16 | 1 | 16 | 0 | 0 | 115 | 28.8 |
| 2 | Old Dominion | 4 | 18 | 1 | 18 | 0 | 0 | 129 | 32.3 |
| 5 | Marshall | 4 | 12 | 2 | 12 | 0 | 0 | 90 | 22.5 |
| 5 | Charlotte | 4 | 13 | 2 | 11 | 1 | 0 | 97 | 24.3 |
| 5 | Middle Tennessee | 4 | 16 | 2 | 15 | 1 | 0 | 119 | 29.8 |
| 8 | UTSA | 4 | 9 | 3 | 8 | 0 | 0 | 71 | 17.8 |
| 8 | North Texas | 4 | 15 | 3 | 14 | 0 | 0 | 113 | 28.3 |
| 8 | Louisiana Tech | 4 | 18 | 3 | 16 | 0 | 0 | 133 | 33.3 |
| 11 | Rice | 4 | 23 | 4 | 22 | 0 | 1 | 174 | 43.5 |
| 12 | Florida International | 4 | 15 | 5 | 13 | 0 | 0 | 118 | 29.5 |
| 12 | Western Kentucky | 3 | 11 | 5 | 11 | 0 | 0 | 92 | 30.7 |
| 14 | UTEP | 4 | 11 | 7 | 11 | 0 | 0 | 98 | 24.5 |