2021 Conference USA Leaders Rushing - Games vs. FBS Power 5 Conference Teams Only through 01/10/2022
| Name | Team | Yr | Pos | G | Att | Yards | Avg. | TD | Att/G | Yards/G | |
|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Brenden Brady | UTSA | SR | RB | 1 | 11 | 67 | 6.09 | 2 | 11.00 | 67.00 |
| 2 | Austin Kendall | La Tech | SR | QB | 2 | 20 | 139 | 6.95 | 1 | 10.00 | 69.50 |
| 2 | Johnny Ford | FAU | SO | RB | 1 | 10 | 52 | 5.20 | 1 | 10.00 | 52.00 |
| 2 | D'vonte Price | FIU | SR | RB | 1 | 15 | 51 | 3.40 | 1 | 15.00 | 51.00 |
| 2 | Isaiah Johnson | N Texas | FR | RB | 1 | 8 | 46 | 5.75 | 1 | 8.00 | 46.00 |
| 2 | Chris Reynolds | Charlotte | SR | QB | 2 | 21 | 72 | 3.43 | 1 | 10.50 | 36.00 |
| 2 | Frank Harris | UTSA | SR | QB | 1 | 8 | 33 | 4.13 | 1 | 8.00 | 33.00 |
| 2 | Jordan Myers | Rice | SR | TE | 2 | 17 | 64 | 3.76 | 1 | 8.50 | 32.00 |
| 2 | Adam Cofield | Western Ky | SR | RB | 2 | 13 | 55 | 4.23 | 1 | 6.50 | 27.50 |