2021 Conference USA Leaders Rushing - Games vs. Ranked Teams Only (AP Poll) through 01/10/2022
| Name | Team | Yr | Pos | G | Att | Yards | Avg. | TD | Att/G | Yards/G | |
|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Rasheen Ali | Marshall | FR | RB | 1 | 20 | 160 | 8.00 | 3 | 20.00 | 160.00 |
| 2 | DeWayne McBride | UAB | SO | RB | 2 | 41 | 244 | 5.95 | 1 | 20.50 | 122.00 |
| 2 | Brenden Brady | UTSA | SR | RB | 1 | 16 | 76 | 4.75 | 1 | 16.00 | 76.00 |
| 2 | Jordan Myers | Rice | SR | TE | 2 | 10 | 23 | 2.30 | 1 | 5.00 | 11.50 |