2021 Conference USA Leaders Passes Defended - Games vs. Ranked Teams Only (AP Poll) through 01/10/2022
| Name | Team | Yr | Pos | G | Int. | Passes Broken Up | Passes Defended | Passes Defended/G | |
|---|---|---|---|---|---|---|---|---|---|
| 1 | Micah Abraham | Marshall | SO | DB | 1 | 0 | 3 | 3 | 3.00 |
| 2 | Dy'jonn Turner | UAB | SR | S | 2 | 0 | 2 | 2 | 1.00 |
| 2 | Miles McCord | Rice | JR | CB | 2 | 0 | 2 | 2 | 1.00 |
| 2 | Naeem Smith | Rice | SR | S | 2 | 0 | 2 | 2 | 1.00 |
| 5 | Sean Fresch | Rice | FR | CB | 2 | 1 | 1 | 2 | 1.00 |
| 5 | BeeJay Williamson | La Tech | SO | DB | 1 | 0 | 1 | 1 | 1.00 |
| 5 | Keivie Rose | La Tech | FR | DL | 1 | 0 | 1 | 1 | 1.00 |
| 5 | Cedric Woods | La Tech | FR | DB | 1 | 0 | 1 | 1 | 1.00 |
| 5 | Trey Baldwin | La Tech | SR | LB | 1 | 0 | 1 | 1 | 1.00 |
| 5 | Nazeeh Johnson | Marshall | SR | S | 1 | 0 | 1 | 1 | 1.00 |
| 5 | Steven Gilmore | Marshall | JR | DB | 1 | 0 | 1 | 1 | 1.00 |
| 5 | Corey Chapman | ODU | FR | S | 1 | 0 | 1 | 1 | 1.00 |
| 5 | Steven Williams | ODU | JR | LB | 1 | 0 | 1 | 1 | 1.00 |
| 5 | Brandon Matterson | UTSA | SR | DL | 1 | 0 | 1 | 1 | 1.00 |
| 5 | Will Ignont | Western Ky | JR | LB | 1 | 0 | 1 | 1 | 1.00 |
| 5 | DeAngelo Malone | Western Ky | SR | DE | 1 | 0 | 1 | 1 | 1.00 |
| 5 | JaQues Evans | Western Ky | FR | DE | 1 | 0 | 1 | 1 | 1.00 |
| 5 | Kaleb Oliver | Western Ky | JR | DB | 1 | 0 | 1 | 1 | 1.00 |
| 5 | Justin Thomas | UAB | SR | OLB | 2 | 0 | 1 | 1 | 0.50 |
| 5 | Jordan Dunbar | Rice | FR | CB | 2 | 0 | 1 | 1 | 0.50 |