2021 Conference USA Leaders Passes Defended - Games vs. Conference Teams Only through 01/10/2022
| Name | Team | Yr | Pos | G | Int. | Passes Broken Up | Passes Defended | Passes Defended/G | |
|---|---|---|---|---|---|---|---|---|---|
| 1 | Roger Cray | ODU | SR | CB | 7 | 1 | 10 | 11 | 1.57 |
| 2 | Natrone Brooks | USM | JR | DB | 8 | 1 | 8 | 9 | 1.13 |
| 2 | Micah Abraham | Marshall | SO | DB | 8 | 0 | 8 | 8 | 1.00 |
| 4 | Starling Thomas V | UAB | JR | CB | 8 | 1 | 7 | 8 | 1.00 |
| 4 | Zyon Gilbert | FAU | SR | CB | 8 | 1 | 7 | 8 | 1.00 |
| 4 | Teldrick Ross | MTSU | SO | S | 7 | 0 | 7 | 7 | 1.00 |
| 4 | Jordan Dunbar | Rice | FR | CB | 8 | 0 | 7 | 7 | 0.88 |
| 8 | Dy'vonne Inyang | UTEP | SR | DB | 6 | 2 | 6 | 8 | 1.33 |
| 8 | Steven Gilmore | Marshall | JR | DB | 8 | 2 | 6 | 8 | 1.00 |
| 8 | Joe Joe Headen | ODU | SR | S | 8 | 2 | 6 | 8 | 1.00 |
| 8 | Jordan Helm | FAU | SR | S | 8 | 1 | 6 | 7 | 0.88 |
| 8 | Reed Blankenship | MTSU | SR | S | 8 | 1 | 6 | 7 | 0.88 |
| 8 | DeShawn Gaddie | N Texas | SO | DB | 8 | 0 | 6 | 6 | 0.75 |
| 8 | Ken Robinson | UTSA | SO | CB | 9 | 0 | 6 | 6 | 0.67 |
| 15 | Quincy Riley | MTSU | FR | CB | 7 | 4 | 5 | 9 | 1.29 |
| 15 | Romain Mungin | FAU | SO | CB | 7 | 2 | 5 | 7 | 1.00 |
| 15 | R'Tarriun Johnson | ODU | JR | S | 8 | 2 | 5 | 7 | 0.88 |
| 15 | Gabe Taylor | Rice | FR | DB | 8 | 2 | 5 | 7 | 0.88 |
| 15 | Keondre Swoopes | UAB | JR | S | 8 | 1 | 5 | 6 | 0.75 |
| 15 | Torey Richardson | UTEP | SO | CB | 8 | 1 | 5 | 6 | 0.75 |
| 15 | Cedric Woods | La Tech | FR | DB | 8 | 0 | 5 | 5 | 0.63 |
| 15 | Trey Creamer | Charlotte | SR | DB | 8 | 0 | 5 | 5 | 0.63 |
| 15 | Tre Hawkins III | ODU | JR | CB | 8 | 0 | 5 | 5 | 0.63 |
| 15 | Sean Fresch | Rice | FR | CB | 8 | 0 | 5 | 5 | 0.63 |
| 15 | Praise Amaewhule | UTEP | SO | DE | 8 | 0 | 5 | 5 | 0.63 |
| 26 | Grayson Cash | UAB | JR | S | 8 | 3 | 4 | 7 | 0.88 |
| 26 | Nazeeh Johnson | Marshall | SR | S | 6 | 2 | 4 | 6 | 1.00 |
| 26 | Korel Smith | FAU | SR | CB | 8 | 2 | 4 | 6 | 0.75 |
| 26 | Will Ignont | Western Ky | JR | LB | 7 | 1 | 4 | 5 | 0.71 |
| 26 | Teja Young | FAU | SO | S | 8 | 1 | 4 | 5 | 0.63 |
| 26 | Miles McCord | Rice | JR | CB | 8 | 1 | 4 | 5 | 0.63 |
| 26 | Dominique Bradshaw | Western Ky | JR | DB | 9 | 1 | 4 | 5 | 0.56 |
| 26 | Antwon Kincade | Western Ky | SR | DB | 9 | 1 | 4 | 5 | 0.56 |
| 26 | Decorian Patterson | MTSU | SO | CB | 7 | 0 | 4 | 4 | 0.57 |
| 26 | Solomon Rogers | Charlotte | JR | DB | 8 | 0 | 4 | 4 | 0.50 |
| 26 | Rashad Wisdom | UTSA | JR | S | 9 | 0 | 4 | 4 | 0.44 |
| 26 | Michael Pitts | Western Ky | SR | DE | 9 | 0 | 4 | 4 | 0.44 |
| 38 | Antonio Parks | UTSA | SR | S | 9 | 2 | 3 | 5 | 0.56 |
| 38 | Corey Mayfield Jr. | UTSA | SR | CB | 9 | 2 | 3 | 5 | 0.56 |
| 38 | Kahlef Hailassie | Western Ky | SO | DB | 9 | 2 | 3 | 5 | 0.56 |
| 38 | Kyle Harrell | UAB | SR | OLB | 8 | 1 | 3 | 4 | 0.50 |
| 38 | Khalil Ladler | La Tech | SR | DB | 8 | 1 | 3 | 4 | 0.50 |
| 38 | Eli Neal | Marshall | SO | LB | 8 | 1 | 3 | 4 | 0.50 |
| 38 | Gregory Grate | MTSU | JR | S | 8 | 1 | 3 | 4 | 0.50 |
| 38 | John Davis | N Texas | JR | DB | 5 | 0 | 3 | 3 | 0.60 |
| 38 | Tariq Woolen | UTSA | SR | CB | 5 | 0 | 3 | 3 | 0.60 |
| 38 | Miguel Edwards | Western Ky | SO | DB | 7 | 0 | 3 | 3 | 0.43 |
| 38 | Tyler Grubbs | La Tech | FR | LB | 8 | 0 | 3 | 3 | 0.38 |
| 38 | Gabriel Murphy | N Texas | FR | DE | 8 | 0 | 3 | 3 | 0.38 |
| 38 | Camron Harrell | USM | JR | DB | 8 | 0 | 3 | 3 | 0.38 |