2019 Conference USA Leaders Total Defense - Games vs. FBS Power 5 Conference Teams Only through 01/13/2020
| Name | G | Rush Yards | Pass Yards | Plays | Total Yards | Yards/Play | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Charlotte | 1 | 235 | 231 | 64 | 466 | 7.28 | 466.0 |
| 2 | UAB | 1 | 121 | 181 | 66 | 302 | 4.58 | 302.0 |
| 3 | Florida International | 1 | 164 | 249 | 67 | 413 | 6.16 | 413.0 |
| 4 | North Texas | 1 | 149 | 129 | 70 | 278 | 3.97 | 278.0 |
| 5 | Florida Atlantic | 1 | 237 | 232 | 74 | 469 | 6.34 | 469.0 |
| 6 | UTEP | 1 | 143 | 281 | 78 | 424 | 5.44 | 424.0 |
| 7 | Old Dominion | 2 | 200 | 447 | 120 | 647 | 5.39 | 323.5 |
| 8 | Western Kentucky | 2 | 459 | 296 | 121 | 755 | 6.24 | 377.5 |
| 9 | Southern Mississippi | 2 | 386 | 514 | 122 | 900 | 7.38 | 450.0 |
| 10 | UTSA | 2 | 635 | 416 | 130 | 1051 | 8.08 | 525.5 |
| 11 | Louisiana Tech | 2 | 227 | 454 | 135 | 681 | 5.04 | 340.5 |
| 12 | Rice | 3 | 496 | 953 | 195 | 1449 | 7.43 | 483.0 |
| 13 | Middle Tennessee | 3 | 810 | 750 | 230 | 1560 | 6.78 | 520.0 |