2018 American Athletic Conference Leaders Total Defense - Games vs. Ranked Teams Only (AP Poll) through 01/07/2019
| Name | G | Rush Yards | Pass Yards | Plays | Total Yards | Yards/Play | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Cincinnati | 1 | 134 | 268 | 61 | 402 | 6.59 | 402.0 |
| 2 | Navy | 4 | 1035 | 780 | 269 | 1815 | 6.75 | 453.8 |
| 3 | UCF | 2 | 413 | 521 | 167 | 934 | 5.59 | 467.0 |
| 4 | Temple | 2 | 518 | 423 | 157 | 941 | 5.99 | 470.5 |
| 5 | Tulsa | 1 | 241 | 237 | 74 | 478 | 6.46 | 478.0 |
| 6 | SMU | 3 | 578 | 874 | 228 | 1452 | 6.37 | 484.0 |
| 7 | South Florida | 2 | 629 | 361 | 158 | 990 | 6.27 | 495.0 |
| 8 | Tulane | 2 | 423 | 593 | 149 | 1016 | 6.82 | 508.0 |
| 9 | East Carolina | 2 | 563 | 505 | 154 | 1068 | 6.94 | 534.0 |
| 10 | Memphis | 2 | 515 | 644 | 156 | 1159 | 7.43 | 579.5 |
| 11 | Houston | 1 | 507 | 85 | 62 | 592 | 9.55 | 592.0 |
| 12 | Connecticut | 4 | 1357 | 1408 | 308 | 2765 | 8.98 | 691.3 |