2018 Conference USA Leaders Opponent First Downs - Games vs. FBS Power 5 Conference Teams Only through 01/07/2019
| Name | G | Rush | Pass | Penalty | Total | Total/G | |
|---|---|---|---|---|---|---|---|
| 1 | Charlotte | 1 | 2 | 7 | 1 | 10 | 10.0 |
| 2 | North Texas | 1 | 4 | 12 | 4 | 20 | 20.0 |
| 3 | Southern Mississippi | 1 | 7 | 8 | 2 | 17 | 17.0 |
| 4 | UAB | 1 | 11 | 9 | 2 | 22 | 22.0 |
| 5 | Florida Atlantic | 1 | 12 | 13 | 1 | 26 | 26.0 |
| 6 | UTEP | 1 | 14 | 9 | 1 | 24 | 24.0 |
| 7 | Marshall | 2 | 15 | 26 | 4 | 45 | 22.5 |
| 7 | Old Dominion | 1 | 15 | 11 | 0 | 26 | 26.0 |
| 9 | Rice | 2 | 19 | 28 | 4 | 51 | 25.5 |
| 10 | Western Kentucky | 2 | 20 | 18 | 3 | 41 | 20.5 |
| 11 | UTSA | 3 | 27 | 36 | 4 | 67 | 22.3 |
| 11 | Florida International | 2 | 27 | 25 | 6 | 58 | 29.0 |
| 13 | Louisiana Tech | 2 | 29 | 19 | 3 | 51 | 25.5 |
| 14 | Middle Tennessee | 3 | 31 | 23 | 3 | 57 | 19.0 |