2018 Conference USA Leaders Total Defense - Games in August/September Only through 01/07/2019
| Name | G | Rush Yards | Pass Yards | Plays | Total Yards | Yards/Play | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Southern Mississippi | 4 | 493 | 663 | 241 | 1156 | 4.80 | 289.0 |
| 2 | UAB | 4 | 695 | 564 | 241 | 1259 | 5.22 | 314.8 |
| 3 | Louisiana Tech | 4 | 636 | 794 | 279 | 1430 | 5.13 | 357.5 |
| 4 | Marshall | 4 | 412 | 1045 | 284 | 1457 | 5.13 | 364.3 |
| 5 | North Texas | 5 | 525 | 1066 | 333 | 1591 | 4.78 | 318.2 |
| 6 | Middle Tennessee | 4 | 811 | 905 | 288 | 1716 | 5.96 | 429.0 |
| 7 | Charlotte | 5 | 514 | 1209 | 276 | 1723 | 6.24 | 344.6 |
| 8 | Western Kentucky | 5 | 813 | 1100 | 345 | 1913 | 5.54 | 382.6 |
| 9 | UTEP | 5 | 1112 | 840 | 312 | 1952 | 6.26 | 390.4 |
| 10 | UTSA | 5 | 701 | 1290 | 311 | 1991 | 6.40 | 398.2 |
| 11 | Florida International | 5 | 925 | 1129 | 355 | 2054 | 5.79 | 410.8 |
| 12 | Florida Atlantic | 5 | 1020 | 1276 | 347 | 2296 | 6.62 | 459.2 |
| 13 | Rice | 5 | 868 | 1554 | 306 | 2422 | 7.92 | 484.4 |
| 14 | Old Dominion | 5 | 1095 | 1450 | 403 | 2545 | 6.32 | 509.0 |