2018 Conference USA Leaders Rushing Defense - Games in August/September Only through 01/07/2019
| Name | G | Att | Yards | Avg. | TD | Att/G | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Southern Mississippi | 4 | 117 | 493 | 4.21 | 2 | 29.25 | 123.25 |
| 2 | Charlotte | 5 | 149 | 514 | 3.45 | 11 | 29.80 | 102.80 |
| 3 | North Texas | 5 | 155 | 525 | 3.39 | 5 | 31.00 | 105.00 |
| 4 | Rice | 5 | 165 | 868 | 5.26 | 9 | 33.00 | 173.60 |
| 5 | Marshall | 4 | 140 | 412 | 2.94 | 6 | 35.00 | 103.00 |
| 6 | UTSA | 5 | 180 | 701 | 3.89 | 8 | 36.00 | 140.20 |
| 6 | Western Kentucky | 5 | 180 | 813 | 4.52 | 5 | 36.00 | 162.60 |
| 8 | UAB | 4 | 155 | 695 | 4.48 | 7 | 38.75 | 173.75 |
| 9 | Florida International | 5 | 199 | 925 | 4.65 | 3 | 39.80 | 185.00 |
| 10 | UTEP | 5 | 200 | 1112 | 5.56 | 9 | 40.00 | 222.40 |
| 11 | Florida Atlantic | 5 | 206 | 1020 | 4.95 | 14 | 41.20 | 204.00 |
| 12 | Middle Tennessee | 4 | 167 | 811 | 4.86 | 8 | 41.75 | 202.75 |
| 13 | Louisiana Tech | 4 | 168 | 636 | 3.79 | 10 | 42.00 | 159.00 |
| 14 | Old Dominion | 5 | 222 | 1095 | 4.93 | 9 | 44.40 | 219.00 |