2016 Atlantic Coast Conference Leaders Opponent First Downs - Games vs. FBS non-Power 5 Conference Teams Only through 01/09/2017
| Name | G | Rush | Pass | Penalty | Total | Total/G | |
|---|---|---|---|---|---|---|---|
| 1 | Virginia Tech | 2 | 18 | 20 | 0 | 38 | 19.0 |
| 2 | Duke | 2 | 14 | 17 | 1 | 32 | 16.0 |
| 3 | Florida State | 1 | 12 | 3 | 2 | 17 | 17.0 |
| 3 | Pittsburgh | 1 | 9 | 7 | 2 | 18 | 18.0 |
| 5 | Boston College | 3 | 3 | 15 | 3 | 21 | 7.0 |
| 5 | Wake Forest | 3 | 29 | 24 | 3 | 56 | 18.7 |
| 5 | Syracuse | 3 | 26 | 39 | 3 | 68 | 22.7 |
| 5 | Georgia Tech | 1 | 14 | 8 | 3 | 25 | 25.0 |
| 9 | North Carolina State | 3 | 19 | 25 | 4 | 48 | 16.0 |
| 9 | Clemson | 1 | 6 | 11 | 4 | 21 | 21.0 |
| 11 | Miami (Florida) | 3 | 20 | 25 | 5 | 50 | 16.7 |
| 12 | Virginia | 2 | 8 | 26 | 6 | 40 | 20.0 |
| 13 | Louisville | 3 | 19 | 23 | 7 | 49 | 16.3 |