2016 Atlantic Coast Conference Leaders Total Defense - Games in October Only through 01/09/2017
| Name | G | Rush Yards | Pass Yards | Plays | Total Yards | Yards/Play | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Louisville | 4 | 409 | 909 | 251 | 1318 | 5.25 | 329.5 |
| 2 | Boston College | 4 | 385 | 1060 | 240 | 1445 | 6.02 | 361.3 |
| 3 | North Carolina | 4 | 661 | 814 | 310 | 1475 | 4.76 | 368.8 |
| 4 | Virginia Tech | 4 | 451 | 1064 | 284 | 1515 | 5.33 | 378.8 |
| 5 | North Carolina State | 5 | 576 | 1323 | 380 | 1899 | 5.00 | 379.8 |
| 6 | Florida State | 4 | 396 | 1181 | 277 | 1577 | 5.69 | 394.3 |
| 7 | Pittsburgh | 4 | 581 | 1054 | 270 | 1635 | 6.06 | 408.8 |
| 8 | Georgia Tech | 4 | 750 | 906 | 264 | 1656 | 6.27 | 414.0 |
| 9 | Clemson | 4 | 719 | 946 | 308 | 1665 | 5.41 | 416.3 |
| 10 | Wake Forest | 4 | 719 | 959 | 290 | 1678 | 5.79 | 419.5 |
| 11 | Duke | 4 | 874 | 830 | 253 | 1704 | 6.74 | 426.0 |
| 12 | Miami (Florida) | 5 | 993 | 1168 | 383 | 2161 | 5.64 | 432.2 |
| 13 | Syracuse | 4 | 757 | 982 | 277 | 1739 | 6.28 | 434.8 |
| 14 | Virginia | 4 | 640 | 1132 | 297 | 1772 | 5.97 | 443.0 |