2016 Atlantic Coast Conference Leaders Rushing Defense - Games vs. Ranked Teams Only (AP Poll) through 01/09/2017
| Name | G | Att | Yards | Avg. | TD | Att/G | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Pittsburgh | 4 | 127 | 374 | 2.94 | 12 | 31.75 | 93.50 |
| 2 | Wake Forest | 4 | 140 | 703 | 5.02 | 9 | 35.00 | 175.75 |
| 3 | Clemson | 7 | 249 | 1090 | 4.38 | 16 | 35.57 | 155.71 |
| 4 | North Carolina State | 3 | 107 | 343 | 3.21 | 6 | 35.67 | 114.33 |
| 5 | Georgia Tech | 3 | 109 | 474 | 4.35 | 6 | 36.33 | 158.00 |
| 6 | Virginia Tech | 2 | 73 | 362 | 4.96 | 7 | 36.50 | 181.00 |
| 7 | Florida State | 5 | 190 | 884 | 4.65 | 14 | 38.00 | 176.80 |
| 8 | Louisville | 3 | 115 | 549 | 4.77 | 2 | 38.33 | 183.00 |
| 9 | Miami (Florida) | 4 | 160 | 641 | 4.01 | 4 | 40.00 | 160.25 |
| 9 | Boston College | 4 | 160 | 843 | 5.27 | 9 | 40.00 | 210.75 |
| 11 | Syracuse | 6 | 244 | 1731 | 7.09 | 23 | 40.67 | 288.50 |
| 12 | Duke | 3 | 127 | 719 | 5.66 | 8 | 42.33 | 239.67 |
| 13 | Virginia | 3 | 134 | 645 | 4.81 | 5 | 44.67 | 215.00 |
| 14 | North Carolina | 4 | 207 | 822 | 3.97 | 11 | 51.75 | 205.50 |