2016 Conference USA Leaders Sacks - Games vs. FBS Power 5 Conference Teams Only through 01/09/2017
| Name | G | Sacks | Sack Yards | Sacks/G | |
|---|---|---|---|---|---|
| 1 | Louisiana Tech | 2 | 6.0 | 46 | 3.00 |
| 2 | Southern Miss | 2 | 5.0 | 37 | 2.50 |
| 2 | Western Kentucky | 2 | 5.0 | 37 | 2.50 |
| 4 | Rice | 2 | 4.0 | 25 | 2.00 |
| 4 | FIU | 2 | 4.0 | 22 | 2.00 |
| 4 | Middle Tennessee State | 2 | 4.0 | 22 | 2.00 |
| 7 | UTEP | 1 | 3.0 | 16 | 3.00 |
| 7 | UTSA | 2 | 3.0 | 15 | 1.50 |
| 9 | Florida Atlantic | 2 | 2.0 | 9 | 1.00 |
| 10 | Old Dominion | 1 | 1.0 | 9 | 1.00 |
| 10 | Marshall | 2 | 1.0 | 8 | 0.50 |