2022 Conference USA Leaders Sacks - Games vs. FBS Power 5 Conference Teams Only through 01/09/2023
| Name | G | Sacks | Sack Yards | Sacks/G | |
|---|---|---|---|---|---|
| 1 | Middle Tennessee | 1 | 4.0 | 27 | 4.00 |
| 1 | Western Kentucky | 2 | 4.0 | 24 | 2.00 |
| 3 | Louisiana Tech | 2 | 2.0 | 13 | 1.00 |
| 3 | Charlotte | 2 | 2.0 | 13 | 1.00 |
| 3 | UTEP | 1 | 2.0 | 10 | 2.00 |
| 6 | Florida Atlantic | 1 | 1.0 | 6 | 1.00 |
| 6 | Rice | 1 | 1.0 | 3 | 1.00 |
| 6 | UAB | 1 | 1.0 | 1 | 1.00 |