2021 Big Ten Conference Leaders Total Defense - Games vs. FBS Power 5 Conference Teams Only through 01/10/2022
| Name | G | Rush Yards | Pass Yards | Plays | Total Yards | Yards/Play | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Wisconsin | 10 | 595 | 1864 | 583 | 2459 | 4.22 | 245.9 |
| 2 | Minnesota | 11 | 1142 | 1949 | 623 | 3091 | 4.96 | 281.0 |
| 3 | Iowa | 12 | 1427 | 2663 | 834 | 4090 | 4.90 | 340.8 |
| 4 | Michigan | 12 | 1483 | 2625 | 817 | 4108 | 5.03 | 342.3 |
| 5 | Illinois | 10 | 1524 | 2111 | 709 | 3635 | 5.13 | 363.5 |
| 6 | Penn State | 11 | 1872 | 2150 | 834 | 4022 | 4.82 | 365.6 |
| 7 | Ohio State | 11 | 1499 | 2615 | 753 | 4114 | 5.46 | 374.0 |
| 8 | Nebraska | 10 | 1499 | 2242 | 687 | 3741 | 5.45 | 374.1 |
| 9 | Purdue | 11 | 1800 | 2391 | 732 | 4191 | 5.73 | 381.0 |
| 10 | Indiana | 9 | 1501 | 2057 | 621 | 3558 | 5.73 | 395.3 |
| 11 | Rutgers | 11 | 1821 | 2808 | 744 | 4629 | 6.22 | 420.8 |
| 12 | Maryland | 11 | 1796 | 2846 | 779 | 4642 | 5.96 | 422.0 |
| 13 | Michigan State | 11 | 1272 | 3597 | 857 | 4869 | 5.68 | 442.6 |
| 14 | Northwestern | 10 | 2349 | 2291 | 719 | 4640 | 6.45 | 464.0 |