2021 Penn State Nittany Lions Total Defense Split Stats through 01/10/2022
| Split | G | Rush Yards | Pass Yards | Plays | Total Yards | Yards/Play | Yards/G |
|---|---|---|---|---|---|---|---|
| All Games | 13 | 1999 | 2598 | 965 | 4597 | 4.76 | 353.6 |
| at Home | 7 | 964 | 1176 | 486 | 2140 | 4.40 | 305.7 |
| on Road/Neutral Site | 6 | 1035 | 1422 | 479 | 2457 | 5.13 | 409.5 |
| in Wins | 7 | 691 | 1477 | 508 | 2168 | 4.27 | 309.7 |
| in Losses | 6 | 1308 | 1121 | 457 | 2429 | 5.32 | 404.8 |
| vs. Conference | 9 | 1337 | 1867 | 677 | 3204 | 4.73 | 356.0 |
| vs. Non-Conference | 4 | 662 | 731 | 288 | 1393 | 4.84 | 348.3 |
| vs. Ranked (AP) | 5 | 951 | 1083 | 369 | 2034 | 5.51 | 406.8 |
| vs. Unranked (AP) | 8 | 1048 | 1515 | 596 | 2563 | 4.30 | 320.4 |
| vs. FBS (I-A) | 12 | 1941 | 2376 | 905 | 4317 | 4.77 | 359.8 |
| vs. FCS (I-AA) | 1 | 58 | 222 | 60 | 280 | 4.67 | 280.0 |
| vs. FBS Winning | 7 | 1179 | 1639 | 549 | 2818 | 5.13 | 402.6 |
| vs. FBS Non-Winning | 5 | 762 | 737 | 356 | 1499 | 4.21 | 299.8 |
| vs. FBS Power 5 | 11 | 1872 | 2150 | 834 | 4022 | 4.82 | 365.6 |
| vs. FBS non-Power 5 | 1 | 69 | 226 | 71 | 295 | 4.15 | 295.0 |
| in August/September | 4 | 489 | 818 | 305 | 1307 | 4.29 | 326.8 |
| in October | 4 | 697 | 733 | 290 | 1430 | 4.93 | 357.5 |
| in November | 4 | 460 | 949 | 292 | 1409 | 4.83 | 352.3 |
| in December/January | 1 | 353 | 98 | 78 | 451 | 5.78 | 451.0 |