2021 Atlantic Coast Conference Leaders Sacks - Games vs. Ranked Teams Only (AP Poll) through 01/10/2022
| Name | G | Sacks | Sack Yards | Sacks/G | |
|---|---|---|---|---|---|
| 1 | Clemson | 4 | 14.0 | 81 | 3.50 |
| 2 | North Carolina | 4 | 13.0 | 82 | 3.25 |
| 2 | Florida State | 4 | 13.0 | 65 | 3.25 |
| 4 | Miami (Florida) | 4 | 9.0 | 80 | 2.25 |
| 4 | Pittsburgh | 3 | 9.0 | 61 | 3.00 |
| 4 | Louisville | 5 | 9.0 | 51 | 1.80 |
| 7 | Syracuse | 4 | 8.0 | 60 | 2.00 |
| 8 | Wake Forest | 3 | 5.0 | 53 | 1.67 |
| 8 | Georgia Tech | 4 | 5.0 | 36 | 1.25 |
| 8 | North Carolina State | 2 | 5.0 | 24 | 2.50 |
| 8 | Boston College | 3 | 5.0 | 17 | 1.67 |
| 8 | Duke | 2 | 5.0 | 15 | 2.50 |
| 13 | Virginia | 4 | 3.0 | 26 | 0.75 |
| 13 | Virginia Tech | 2 | 3.0 | 14 | 1.50 |