2021 Atlantic Coast Conference Leaders Sacks - Games in October Only through 01/10/2022
| Name | G | Sacks | Sack Yards | Sacks/G | |
|---|---|---|---|---|---|
| 1 | Syracuse | 5 | 15.0 | 104 | 3.00 |
| 2 | Clemson | 4 | 13.0 | 85 | 3.25 |
| 2 | North Carolina State | 4 | 13.0 | 59 | 3.25 |
| 4 | Duke | 4 | 11.0 | 68 | 2.75 |
| 4 | Louisville | 4 | 11.0 | 68 | 2.75 |
| 6 | Miami (Florida) | 3 | 9.0 | 78 | 3.00 |
| 6 | Pittsburgh | 4 | 9.0 | 68 | 2.25 |
| 6 | North Carolina | 4 | 9.0 | 52 | 2.25 |
| 6 | Wake Forest | 4 | 9.0 | 42 | 2.25 |
| 6 | Florida State | 4 | 9.0 | 41 | 2.25 |
| 11 | Virginia Tech | 4 | 6.0 | 33 | 1.50 |
| 12 | Boston College | 4 | 5.0 | 52 | 1.25 |
| 12 | Georgia Tech | 4 | 5.0 | 35 | 1.25 |
| 14 | Virginia | 4 | 2.0 | 13 | 0.50 |