2021 Big 12 Conference Leaders Opponent First Downs - Games vs. FBS Power 5 Conference Teams Only through 01/10/2022
| Name | G | Rush | Pass | Penalty | Total | Total/G | |
|---|---|---|---|---|---|---|---|
| 1 | Oklahoma State | 10 | 47 | 69 | 17 | 133 | 13.3 |
| 2 | Iowa State | 11 | 88 | 96 | 12 | 196 | 17.8 |
| 3 | West Virginia | 12 | 94 | 111 | 11 | 216 | 18.0 |
| 4 | Kansas State | 11 | 81 | 106 | 15 | 202 | 18.4 |
| 5 | Baylor | 11 | 81 | 113 | 25 | 219 | 19.9 |
| 6 | Oklahoma | 11 | 90 | 132 | 17 | 239 | 21.7 |
| 7 | Texas | 10 | 103 | 106 | 16 | 225 | 22.5 |
| 8 | TCU | 10 | 103 | 104 | 20 | 227 | 22.7 |
| 9 | Texas Tech | 10 | 87 | 130 | 13 | 230 | 23.0 |
| 10 | Kansas | 10 | 132 | 104 | 10 | 246 | 24.6 |