2021 Big 12 Conference Leaders Opponent First Downs - Games vs. Conference Teams Only through 01/10/2022
| Name | G | Rush | Pass | Penalty | Total | Total/G | |
|---|---|---|---|---|---|---|---|
| 1 | Oklahoma State | 10 | 47 | 69 | 17 | 133 | 13.3 |
| 2 | West Virginia | 9 | 63 | 86 | 8 | 157 | 17.4 |
| 3 | Iowa State | 9 | 75 | 81 | 9 | 165 | 18.3 |
| 4 | Kansas State | 9 | 69 | 93 | 11 | 173 | 19.2 |
| 5 | Baylor | 10 | 69 | 106 | 24 | 199 | 19.9 |
| 6 | Oklahoma | 9 | 73 | 107 | 15 | 195 | 21.7 |
| 7 | Texas | 9 | 87 | 101 | 16 | 204 | 22.7 |
| 8 | Texas Tech | 9 | 83 | 113 | 12 | 208 | 23.1 |
| 9 | TCU | 9 | 97 | 96 | 18 | 211 | 23.4 |
| 10 | Kansas | 9 | 119 | 91 | 9 | 219 | 24.3 |