2021 Iowa State Cyclones Opponent First Down Split Stats through 01/10/2022
| Split | G | Rush | Pass | Penalty | Total |
|---|---|---|---|---|---|
| All Games | 13 | 96 | 107 | 13 | 216 |
| at Home | 6 | 42 | 41 | 4 | 87 |
| on Road/Neutral Site | 7 | 54 | 66 | 9 | 129 |
| in Wins | 7 | 48 | 51 | 5 | 104 |
| in Losses | 6 | 48 | 56 | 8 | 112 |
| vs. Conference | 9 | 75 | 81 | 9 | 165 |
| vs. Non-Conference | 4 | 21 | 26 | 4 | 51 |
| vs. Ranked (AP) | 5 | 36 | 35 | 6 | 77 |
| vs. Unranked (AP) | 8 | 60 | 72 | 7 | 139 |
| vs. FBS (I-A) | 12 | 91 | 99 | 13 | 203 |
| vs. FCS (I-AA) | 1 | 5 | 8 | 0 | 13 |
| vs. FBS Winning | 7 | 54 | 59 | 8 | 121 |
| vs. FBS Non-Winning | 5 | 37 | 40 | 5 | 82 |
| vs. FBS Power 5 | 11 | 88 | 96 | 12 | 196 |
| vs. FBS non-Power 5 | 1 | 3 | 3 | 1 | 7 |
| in August/September | 4 | 22 | 22 | 2 | 46 |
| in October | 4 | 30 | 47 | 6 | 83 |
| in November | 4 | 36 | 28 | 3 | 67 |
| in December/January | 1 | 8 | 10 | 2 | 20 |